A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and transforming growth factor-α (TGF-α), to the initiation of intracellular signaling pathways. EGFR binds to EGF and TGF-α with similar affinity, but generates d...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yongjian, Ognjenovic, Jana, Karandur, Deepti, Miller, Kate, Merk, Alan, Subramaniam, Sriram, Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716103/
https://www.ncbi.nlm.nih.gov/pubmed/34846302
http://dx.doi.org/10.7554/eLife.73218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716103/
https://www.ncbi.nlm.nih.gov/pubmed/34846302
http://dx.doi.org/10.7554/eLife.73218

Ejemplares similares