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A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and transforming growth factor-α (TGF-α), to the initiation of intracellular signaling pathways. EGFR binds to EGF and TGF-α with similar affinity, but generates d...

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Detalles Bibliográficos
Autores principales:	Huang, Yongjian, Ognjenovic, Jana, Karandur, Deepti, Miller, Kate, Merk, Alan, Subramaniam, Sriram, Kuriyan, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716103/ https://www.ncbi.nlm.nih.gov/pubmed/34846302 http://dx.doi.org/10.7554/eLife.73218

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