A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male

Drug-drug interactions in medications metabolized by cytochrome P450 enzymes can lead to multi-organ complications. An uncommon but serious potential adverse effect of statins is rhabdomyolysis, most commonly triggered by drug interactions. Rhabdomyolysis presents with markedly elevated creatine kin...

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Detalles Bibliográficos
Autores principales: Osborn, Harmony, Grossman, Daniel, Kochhar, Smriti, Kanukuntla, Anish, Kata, Priyaranjan, Cheriyath, Pramil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716163/
https://www.ncbi.nlm.nih.gov/pubmed/34987920
http://dx.doi.org/10.7759/cureus.20035
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author Osborn, Harmony
Grossman, Daniel
Kochhar, Smriti
Kanukuntla, Anish
Kata, Priyaranjan
Cheriyath, Pramil
author_facet Osborn, Harmony
Grossman, Daniel
Kochhar, Smriti
Kanukuntla, Anish
Kata, Priyaranjan
Cheriyath, Pramil
author_sort Osborn, Harmony
collection PubMed
description Drug-drug interactions in medications metabolized by cytochrome P450 enzymes can lead to multi-organ complications. An uncommon but serious potential adverse effect of statins is rhabdomyolysis, most commonly triggered by drug interactions. Rhabdomyolysis presents with markedly elevated creatine kinase levels, dark urine, and often myoglobinuria. The breakdown of the muscles during rhabdomyolysis can be toxic to the kidneys, often precipitating acute kidney injury (AKI) and can also damage the liver, causing transaminitis. This study presents a case of a 66-year-old male with delayed onset complex pharmacological interaction between ticagrelor, rosuvastatin, and amiodarone resulting in rhabdomyolysis, AKI, and transaminitis.
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spelling pubmed-87161632022-01-04 A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male Osborn, Harmony Grossman, Daniel Kochhar, Smriti Kanukuntla, Anish Kata, Priyaranjan Cheriyath, Pramil Cureus Internal Medicine Drug-drug interactions in medications metabolized by cytochrome P450 enzymes can lead to multi-organ complications. An uncommon but serious potential adverse effect of statins is rhabdomyolysis, most commonly triggered by drug interactions. Rhabdomyolysis presents with markedly elevated creatine kinase levels, dark urine, and often myoglobinuria. The breakdown of the muscles during rhabdomyolysis can be toxic to the kidneys, often precipitating acute kidney injury (AKI) and can also damage the liver, causing transaminitis. This study presents a case of a 66-year-old male with delayed onset complex pharmacological interaction between ticagrelor, rosuvastatin, and amiodarone resulting in rhabdomyolysis, AKI, and transaminitis. Cureus 2021-11-30 /pmc/articles/PMC8716163/ /pubmed/34987920 http://dx.doi.org/10.7759/cureus.20035 Text en Copyright © 2021, Osborn et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Osborn, Harmony
Grossman, Daniel
Kochhar, Smriti
Kanukuntla, Anish
Kata, Priyaranjan
Cheriyath, Pramil
A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male
title A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male
title_full A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male
title_fullStr A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male
title_full_unstemmed A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male
title_short A Rare Case of Delayed Onset Multi-Drug Interaction Resulting in Rhabdomyolysis in a 66-Year-Old Male
title_sort rare case of delayed onset multi-drug interaction resulting in rhabdomyolysis in a 66-year-old male
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716163/
https://www.ncbi.nlm.nih.gov/pubmed/34987920
http://dx.doi.org/10.7759/cureus.20035
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