A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2

Case reports have discussed coronavirus disease of 2019 (COVID-19) patients presenting with hemolytic anemia, specifically with a positive direct antiglobulin test. However, Coombs-negative hemolytic anemia in COVID-19 patients has been rarely reported. We present an unusual case of Coombs-negative...

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Autores principales: Neerukonda, Thanuja, Moughabel, Walid, Chen, Justin, Patel, Devansh, Manji, Faiza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716164/
https://www.ncbi.nlm.nih.gov/pubmed/34987919
http://dx.doi.org/10.7759/cureus.20034
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author Neerukonda, Thanuja
Moughabel, Walid
Chen, Justin
Patel, Devansh
Manji, Faiza
author_facet Neerukonda, Thanuja
Moughabel, Walid
Chen, Justin
Patel, Devansh
Manji, Faiza
author_sort Neerukonda, Thanuja
collection PubMed
description Case reports have discussed coronavirus disease of 2019 (COVID-19) patients presenting with hemolytic anemia, specifically with a positive direct antiglobulin test. However, Coombs-negative hemolytic anemia in COVID-19 patients has been rarely reported. We present an unusual case of Coombs-negative hemolytic anemia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which responded with evidence-based COVID-19 treatments. We demonstrate the importance of considering SARS-CoV-2 as a cause of Coombs-negative hemolytic anemia, and we illustrate how treatment of the underlying COVID-19 illness, even if it is just supportive care, will help resolve the associated hemolysis.
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spelling pubmed-87161642022-01-04 A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2 Neerukonda, Thanuja Moughabel, Walid Chen, Justin Patel, Devansh Manji, Faiza Cureus Internal Medicine Case reports have discussed coronavirus disease of 2019 (COVID-19) patients presenting with hemolytic anemia, specifically with a positive direct antiglobulin test. However, Coombs-negative hemolytic anemia in COVID-19 patients has been rarely reported. We present an unusual case of Coombs-negative hemolytic anemia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which responded with evidence-based COVID-19 treatments. We demonstrate the importance of considering SARS-CoV-2 as a cause of Coombs-negative hemolytic anemia, and we illustrate how treatment of the underlying COVID-19 illness, even if it is just supportive care, will help resolve the associated hemolysis. Cureus 2021-11-30 /pmc/articles/PMC8716164/ /pubmed/34987919 http://dx.doi.org/10.7759/cureus.20034 Text en Copyright © 2021, Neerukonda et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Neerukonda, Thanuja
Moughabel, Walid
Chen, Justin
Patel, Devansh
Manji, Faiza
A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2
title A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2
title_full A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2
title_fullStr A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2
title_full_unstemmed A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2
title_short A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2
title_sort case of coombs-negative hemolytic anemia prompting diagnosis of sars‐cov‐2
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716164/
https://www.ncbi.nlm.nih.gov/pubmed/34987919
http://dx.doi.org/10.7759/cureus.20034
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