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Intranasal immunization with a Middle East respiratory syndrome-coronavirus antigen conjugated to the M-cell targeting ligand Co4B enhances antigen-specific mucosal and systemic immunity and protects against infection

Middle East respiratory syndrome (MERS) is a threat to public health worldwide. A vaccine against the causative agent of MERS, MERS-coronavirus (MERS-CoV), is urgently needed. We previously identified a peptide ligand, Co4B, which can enhance antigen (Ag) delivery to the nasal mucosa and promote Ag-...

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Detalles Bibliográficos
Autores principales:	Yang, Ye Lin, Kim, Ju, Jeong, Yongsu, Jang, Yong-Suk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716170/ https://www.ncbi.nlm.nih.gov/pubmed/34991928 http://dx.doi.org/10.1016/j.vaccine.2021.12.057

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