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The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review
BACKGROUND: Considering that the oral cavity is a major entryway and reservoir for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aim of the authors was to perform a systematic review of in vivo and in vitro studies to assess the effectiveness of mouthrinses on SARS-CoV-2 viral lo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Dental Association.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716175/ https://www.ncbi.nlm.nih.gov/pubmed/35287944 http://dx.doi.org/10.1016/j.adaj.2021.12.007 |
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author | Silva, António Azevedo, Maria Sampaio-Maia, Benedita Sousa-Pinto, Bernardo |
author_facet | Silva, António Azevedo, Maria Sampaio-Maia, Benedita Sousa-Pinto, Bernardo |
author_sort | Silva, António |
collection | PubMed |
description | BACKGROUND: Considering that the oral cavity is a major entryway and reservoir for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aim of the authors was to perform a systematic review of in vivo and in vitro studies to assess the effectiveness of mouthrinses on SARS-CoV-2 viral load. TYPES OF STUDIES REVIEWED: The authors searched PubMed, Web of Science, Scopus, MedRxiv, and bioRxiv databases, including in vitro and in vivo studies assessing the virucidal effect of mouthrinses on SARS-CoV-2 or surrogates. From a total of 1,622 articles retrieved, the authors included 39 in this systematic review. RESULTS: Povidone-iodine was the most studied mouthrinse (14 in vitro and 9 in vivo studies), frequently showing significant reductions in viral load in in vitro assays. Similarly, cetylpyridinium chloride also showed good results, although it was evaluated in fewer studies. Chlorhexidine gluconate and hydrogen peroxide showed conflicting results on SARS-CoV-2 load reduction in both in vitro and in vivo studies. PRACTICAL IMPLICATIONS: Povidone-iodine–based mouthrinses appear to be the best option as an oral prerinse in the dental context for SARS-CoV-2 viral load reduction. Although the results of primary studies are relevant, there is a need for more in vivo studies on mouthrinses, in particular, randomized controlled clinical trials, to better understand their effect on SARS-CoV-2 viral load and infection prevention. |
format | Online Article Text |
id | pubmed-8716175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Dental Association. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87161752021-12-30 The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review Silva, António Azevedo, Maria Sampaio-Maia, Benedita Sousa-Pinto, Bernardo J Am Dent Assoc Systematic Review BACKGROUND: Considering that the oral cavity is a major entryway and reservoir for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aim of the authors was to perform a systematic review of in vivo and in vitro studies to assess the effectiveness of mouthrinses on SARS-CoV-2 viral load. TYPES OF STUDIES REVIEWED: The authors searched PubMed, Web of Science, Scopus, MedRxiv, and bioRxiv databases, including in vitro and in vivo studies assessing the virucidal effect of mouthrinses on SARS-CoV-2 or surrogates. From a total of 1,622 articles retrieved, the authors included 39 in this systematic review. RESULTS: Povidone-iodine was the most studied mouthrinse (14 in vitro and 9 in vivo studies), frequently showing significant reductions in viral load in in vitro assays. Similarly, cetylpyridinium chloride also showed good results, although it was evaluated in fewer studies. Chlorhexidine gluconate and hydrogen peroxide showed conflicting results on SARS-CoV-2 load reduction in both in vitro and in vivo studies. PRACTICAL IMPLICATIONS: Povidone-iodine–based mouthrinses appear to be the best option as an oral prerinse in the dental context for SARS-CoV-2 viral load reduction. Although the results of primary studies are relevant, there is a need for more in vivo studies on mouthrinses, in particular, randomized controlled clinical trials, to better understand their effect on SARS-CoV-2 viral load and infection prevention. American Dental Association. 2022-07 2021-12-30 /pmc/articles/PMC8716175/ /pubmed/35287944 http://dx.doi.org/10.1016/j.adaj.2021.12.007 Text en © 2022 American Dental Association. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Systematic Review Silva, António Azevedo, Maria Sampaio-Maia, Benedita Sousa-Pinto, Bernardo The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review |
title | The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review |
title_full | The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review |
title_fullStr | The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review |
title_full_unstemmed | The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review |
title_short | The effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: A systematic review |
title_sort | effect of mouthrinses on severe acute respiratory syndrome coronavirus 2 viral load: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716175/ https://www.ncbi.nlm.nih.gov/pubmed/35287944 http://dx.doi.org/10.1016/j.adaj.2021.12.007 |
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