The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

As natural nanocarriers and intercellular messengers, extracellular vesicles (EVs) control communication among cells. Under physiological and pathological conditions, EVs deliver generic information including proteins and nucleic acids to recipient cells and exert regulatory effects. Macrophages hel...

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Autores principales: Xing, Yi, Sun, Xun, Dou, Yiming, Wang, Min, Zhao, Yanmei, Yang, Qiang, Zhao, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716390/
https://www.ncbi.nlm.nih.gov/pubmed/34975877
http://dx.doi.org/10.3389/fimmu.2021.785728
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author Xing, Yi
Sun, Xun
Dou, Yiming
Wang, Min
Zhao, Yanmei
Yang, Qiang
Zhao, Yanhong
author_facet Xing, Yi
Sun, Xun
Dou, Yiming
Wang, Min
Zhao, Yanmei
Yang, Qiang
Zhao, Yanhong
author_sort Xing, Yi
collection PubMed
description As natural nanocarriers and intercellular messengers, extracellular vesicles (EVs) control communication among cells. Under physiological and pathological conditions, EVs deliver generic information including proteins and nucleic acids to recipient cells and exert regulatory effects. Macrophages help mediate immune responses, and macrophage-derived EVs may play immunomodulatory roles in the progression of chronic inflammatory diseases. Furthermore, EVs derived from various macrophage phenotypes have different biological functions. In this review, we describe the pathophysiological significance of macrophage-derived extracellular vesicles in the development of chronic inflammatory diseases, including diabetes, cancer, cardiovascular disease, pulmonary disease, and gastrointestinal disease, and the potential applications of these EVs.
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spelling pubmed-87163902021-12-31 The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases Xing, Yi Sun, Xun Dou, Yiming Wang, Min Zhao, Yanmei Yang, Qiang Zhao, Yanhong Front Immunol Immunology As natural nanocarriers and intercellular messengers, extracellular vesicles (EVs) control communication among cells. Under physiological and pathological conditions, EVs deliver generic information including proteins and nucleic acids to recipient cells and exert regulatory effects. Macrophages help mediate immune responses, and macrophage-derived EVs may play immunomodulatory roles in the progression of chronic inflammatory diseases. Furthermore, EVs derived from various macrophage phenotypes have different biological functions. In this review, we describe the pathophysiological significance of macrophage-derived extracellular vesicles in the development of chronic inflammatory diseases, including diabetes, cancer, cardiovascular disease, pulmonary disease, and gastrointestinal disease, and the potential applications of these EVs. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8716390/ /pubmed/34975877 http://dx.doi.org/10.3389/fimmu.2021.785728 Text en Copyright © 2021 Xing, Sun, Dou, Wang, Zhao, Yang and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xing, Yi
Sun, Xun
Dou, Yiming
Wang, Min
Zhao, Yanmei
Yang, Qiang
Zhao, Yanhong
The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases
title The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases
title_full The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases
title_fullStr The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases
title_full_unstemmed The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases
title_short The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases
title_sort immuno-modulation effect of macrophage-derived extracellular vesicles in chronic inflammatory diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716390/
https://www.ncbi.nlm.nih.gov/pubmed/34975877
http://dx.doi.org/10.3389/fimmu.2021.785728
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