Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer

Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors for the treatment of ovarian and breast cance...

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Autores principales: Sha, Huanhuan, Gan, Yujie, Zou, Renrui, Wu, Jianzhong, Feng, Jifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716401/
https://www.ncbi.nlm.nih.gov/pubmed/34976832
http://dx.doi.org/10.3389/fonc.2021.790967
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author Sha, Huanhuan
Gan, Yujie
Zou, Renrui
Wu, Jianzhong
Feng, Jifeng
author_facet Sha, Huanhuan
Gan, Yujie
Zou, Renrui
Wu, Jianzhong
Feng, Jifeng
author_sort Sha, Huanhuan
collection PubMed
description Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors for the treatment of ovarian and breast cancers has advanced research on other PARP family members for the treatment of cancer. This paper reviews the role of PARP family members (except PARP1/2 and tankyrases) in cancer and the underlying regulatory mechanisms, which will establish a molecular basis for the clinical application of PARPs in the future.
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spelling pubmed-87164012021-12-31 Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer Sha, Huanhuan Gan, Yujie Zou, Renrui Wu, Jianzhong Feng, Jifeng Front Oncol Oncology Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors for the treatment of ovarian and breast cancers has advanced research on other PARP family members for the treatment of cancer. This paper reviews the role of PARP family members (except PARP1/2 and tankyrases) in cancer and the underlying regulatory mechanisms, which will establish a molecular basis for the clinical application of PARPs in the future. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8716401/ /pubmed/34976832 http://dx.doi.org/10.3389/fonc.2021.790967 Text en Copyright © 2021 Sha, Gan, Zou, Wu and Feng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sha, Huanhuan
Gan, Yujie
Zou, Renrui
Wu, Jianzhong
Feng, Jifeng
Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
title Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
title_full Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
title_fullStr Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
title_full_unstemmed Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
title_short Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
title_sort research advances in the role of the poly adp ribose polymerase family in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716401/
https://www.ncbi.nlm.nih.gov/pubmed/34976832
http://dx.doi.org/10.3389/fonc.2021.790967
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