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Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat

The telencephalon develops from the alar plate of the secondary prosencephalon and is subdivided into two distinct divisions, the pallium, which derives solely from prosomere hp1, and the subpallium which derives from both hp1 and hp2 prosomeres. In this first systematic analysis of the feline telen...

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Autores principales: Siskos, Nikistratos, Ververidis, Charalampos, Skavdis, George, Grigoriou, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716433/
https://www.ncbi.nlm.nih.gov/pubmed/34975420
http://dx.doi.org/10.3389/fnana.2021.785541
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author Siskos, Nikistratos
Ververidis, Charalampos
Skavdis, George
Grigoriou, Maria E.
author_facet Siskos, Nikistratos
Ververidis, Charalampos
Skavdis, George
Grigoriou, Maria E.
author_sort Siskos, Nikistratos
collection PubMed
description The telencephalon develops from the alar plate of the secondary prosencephalon and is subdivided into two distinct divisions, the pallium, which derives solely from prosomere hp1, and the subpallium which derives from both hp1 and hp2 prosomeres. In this first systematic analysis of the feline telencephalon genoarchitecture, we apply the prosomeric model to compare the expression of a battery of genes, including Tbr1, Tbr2, Pax6, Mash1, Dlx2, Nkx2-1, Lhx6, Lhx7, Lhx2, and Emx1, the orthologs of which alone or in combination, demarcate molecularly distinct territories in other species. We characterize, within the pallium and the subpallium, domains and subdomains topologically equivalent to those previously described in other vertebrate species and we show that the overall genoarchitectural map of the E26/27 feline brain is highly similar to that of the E13.5/E14 mouse. In addition, using the same approach at the earlier (E22/23 and E24/25) or later (E28/29 and E34/35) stages we further analyze neurogenesis, define the timing and duration of several developmental events, and compare our data with those from similar mouse studies; our results point to a complex pattern of heterochronies and show that, compared with the mouse, developmental events in the feline telencephalon span over extended periods suggesting that cats may provide a useful animal model to study brain patterning in ontogenesis and evolution.
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spelling pubmed-87164332021-12-31 Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat Siskos, Nikistratos Ververidis, Charalampos Skavdis, George Grigoriou, Maria E. Front Neuroanat Neuroanatomy The telencephalon develops from the alar plate of the secondary prosencephalon and is subdivided into two distinct divisions, the pallium, which derives solely from prosomere hp1, and the subpallium which derives from both hp1 and hp2 prosomeres. In this first systematic analysis of the feline telencephalon genoarchitecture, we apply the prosomeric model to compare the expression of a battery of genes, including Tbr1, Tbr2, Pax6, Mash1, Dlx2, Nkx2-1, Lhx6, Lhx7, Lhx2, and Emx1, the orthologs of which alone or in combination, demarcate molecularly distinct territories in other species. We characterize, within the pallium and the subpallium, domains and subdomains topologically equivalent to those previously described in other vertebrate species and we show that the overall genoarchitectural map of the E26/27 feline brain is highly similar to that of the E13.5/E14 mouse. In addition, using the same approach at the earlier (E22/23 and E24/25) or later (E28/29 and E34/35) stages we further analyze neurogenesis, define the timing and duration of several developmental events, and compare our data with those from similar mouse studies; our results point to a complex pattern of heterochronies and show that, compared with the mouse, developmental events in the feline telencephalon span over extended periods suggesting that cats may provide a useful animal model to study brain patterning in ontogenesis and evolution. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8716433/ /pubmed/34975420 http://dx.doi.org/10.3389/fnana.2021.785541 Text en Copyright © 2021 Siskos, Ververidis, Skavdis and Grigoriou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroanatomy
Siskos, Nikistratos
Ververidis, Charalampos
Skavdis, George
Grigoriou, Maria E.
Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat
title Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat
title_full Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat
title_fullStr Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat
title_full_unstemmed Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat
title_short Genoarchitectonic Compartmentalization of the Embryonic Telencephalon: Insights From the Domestic Cat
title_sort genoarchitectonic compartmentalization of the embryonic telencephalon: insights from the domestic cat
topic Neuroanatomy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716433/
https://www.ncbi.nlm.nih.gov/pubmed/34975420
http://dx.doi.org/10.3389/fnana.2021.785541
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