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Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study

Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a...

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Autores principales: Veronese, Nicola, Stefanac, Sinisa, Koyanagi, Ai, Al-Daghri, Nasser M., Sabico, Shaun, Cooper, Cyrus, Rizzoli, Renè, Reginster, Jean-Yves, Barbagallo, Mario, Dominguez, Ligia J., Smith, Lee, Maggi, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716541/
https://www.ncbi.nlm.nih.gov/pubmed/34975772
http://dx.doi.org/10.3389/fendo.2021.804560
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author Veronese, Nicola
Stefanac, Sinisa
Koyanagi, Ai
Al-Daghri, Nasser M.
Sabico, Shaun
Cooper, Cyrus
Rizzoli, Renè
Reginster, Jean-Yves
Barbagallo, Mario
Dominguez, Ligia J.
Smith, Lee
Maggi, Stefania
author_facet Veronese, Nicola
Stefanac, Sinisa
Koyanagi, Ai
Al-Daghri, Nasser M.
Sabico, Shaun
Cooper, Cyrus
Rizzoli, Renè
Reginster, Jean-Yves
Barbagallo, Mario
Dominguez, Ligia J.
Smith, Lee
Maggi, Stefania
author_sort Veronese, Nicola
collection PubMed
description Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p<0.0001). Using a logistic regression analysis, adjusting for potential confounders at baseline and the diagnosis of sarcopenia during follow-up, sarcopenia was associated with a higher incidence of knee SxOA (odds ratio, OR=2.29; 95%CI [confidence interval]: 1.42-3.71; p=0.001), but not knee ROA (OR=1.48; 95%CI: 0.53-4.10; p=0.45). In conclusion, sarcopenia could be associated with a higher risk of negative knee OA outcomes, in particular symptomatic forms.
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spelling pubmed-87165412021-12-31 Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study Veronese, Nicola Stefanac, Sinisa Koyanagi, Ai Al-Daghri, Nasser M. Sabico, Shaun Cooper, Cyrus Rizzoli, Renè Reginster, Jean-Yves Barbagallo, Mario Dominguez, Ligia J. Smith, Lee Maggi, Stefania Front Endocrinol (Lausanne) Endocrinology Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p<0.0001). Using a logistic regression analysis, adjusting for potential confounders at baseline and the diagnosis of sarcopenia during follow-up, sarcopenia was associated with a higher incidence of knee SxOA (odds ratio, OR=2.29; 95%CI [confidence interval]: 1.42-3.71; p=0.001), but not knee ROA (OR=1.48; 95%CI: 0.53-4.10; p=0.45). In conclusion, sarcopenia could be associated with a higher risk of negative knee OA outcomes, in particular symptomatic forms. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8716541/ /pubmed/34975772 http://dx.doi.org/10.3389/fendo.2021.804560 Text en Copyright © 2021 Veronese, Stefanac, Koyanagi, Al-Daghri, Sabico, Cooper, Rizzoli, Reginster, Barbagallo, Dominguez, Smith and Maggi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Veronese, Nicola
Stefanac, Sinisa
Koyanagi, Ai
Al-Daghri, Nasser M.
Sabico, Shaun
Cooper, Cyrus
Rizzoli, Renè
Reginster, Jean-Yves
Barbagallo, Mario
Dominguez, Ligia J.
Smith, Lee
Maggi, Stefania
Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
title Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
title_full Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
title_fullStr Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
title_full_unstemmed Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
title_short Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
title_sort lower limb muscle strength and muscle mass are associated with incident symptomatic knee osteoarthritis: a longitudinal cohort study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716541/
https://www.ncbi.nlm.nih.gov/pubmed/34975772
http://dx.doi.org/10.3389/fendo.2021.804560
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