Cargando…

Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by Antidepressants

Commonly prescribed antidepressants may be associated with protection against severe COVID-19. The mechanism of their action in this context, however, remains unknown. Here, I investigated the effect of an antidepressant drug fluvoxamine on membrane trafficking of the SARS-CoV-2 spike protein and it...

Descripción completa

Detalles Bibliográficos
Autor principal:	Glebov, Oleg O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716620/ https://www.ncbi.nlm.nih.gov/pubmed/34975483 http://dx.doi.org/10.3389/fphar.2021.787261

Ejemplares similares

Tolerability and safety of fluvoxamine and other antidepressants
por: Westenberg, HGM, et al.
Publicado: (2006)

Hormone-stimulated modulation of endocytic trafficking in osteoclasts
por: Stenbeck, Gudrun, et al.
Publicado: (2012)

Papillomaviruses and Endocytic Trafficking
por: Siddiqa, Abida, et al.
Publicado: (2018)

Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19
por: Mahdi, Mohamed, et al.
Publicado: (2022)

Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19
por: Sukhatme, Vikas P., et al.
Publicado: (2021)

CYP2D6 gene polymorphism and apatinib affect the metabolic profile of fluvoxamine
por: Ye, Zhize, et al.
Publicado: (2022)

The endocytic trafficking pathway of oncogenic papillomaviruses
por: Mikuličić, Snježana, et al.
Publicado: (2019)

Fluvoxamine
por: DeVane, C Lindsay
Publicado: (2005)

An Overview of Fluvoxamine and its Use in SARS-CoV-2 Treatment
por: Arishi, Naif A, et al.
Publicado: (2023)

Impact of fluvoxamine on outpatient treatment of COVID-19 in Honduras in a prospective observational real-world study
por: Pineda, Estela, et al.
Publicado: (2022)

Regulation of Fc Receptor Endocytic Trafficking by Ubiquitination
por: Molfetta, Rosa, et al.
Publicado: (2014)

Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
por: Swiatecka-Urban, Agnieszka
Publicado: (2017)

Membrane Heterogeneity Controls Cellular Endocytic Trafficking
por: Redpath, Gregory M. I., et al.
Publicado: (2020)

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San
por: Park, Bo-Kyung, et al.
Publicado: (2020)

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
por: Shinde, Swapnil Rohidas, et al.
Publicado: (2016)

The Anti-inflammatory Effect of the Tricyclic Antidepressant Clomipramine and Its High Penetration in the Brain Might Be Useful to Prevent the Psychiatric Consequences of SARS-CoV-2 Infection
por: Nobile, B., et al.
Publicado: (2021)

Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing
por: Glebov, Oleg O.
Publicado: (2020)

Dose-Dependent Antidepressant-Like Effects of Cannabidiol in Aged Rats
por: Hernández-Hernández, Elena, et al.
Publicado: (2022)

Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells
por: Raghavan, Somasundaram, et al.
Publicado: (2022)

Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development
por: Liu, Xiao-Huan, et al.
Publicado: (2022)

SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway
por: Zhao, Lin, et al.
Publicado: (2021)

Differential Requirements in Endocytic Trafficking for Penetration of Dengue Virus
por: Acosta, Eliana G., et al.
Publicado: (2012)

The role of endocytic trafficking in antigen T cell receptor activation
por: Evnouchidou, Irini, et al.
Publicado: (2022)

Evaluation of the Effect of Antidepressant Drug, Fluvoxamine, on Cyclooxygenase-2 Protein Expression in Lipopolysaccharide-stimulated Macrophages
por: Naji Esfahani, Hajar, et al.
Publicado: (2019)

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
por: Dey, Debajit, et al.
Publicado: (2022)

Arl13b regulates early endocytic vesicle trafficking
por: Barral, DC, et al.
Publicado: (2012)

Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides
por: Wang, Shiyu, et al.
Publicado: (2016)

Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking
por: Fraser, Jane, et al.
Publicado: (2017)

Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins
por: Ecker, Manuela, et al.
Publicado: (2021)

Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling
por: Jullié, Damien, et al.
Publicado: (2022)

Conserved NIMA kinases regulate multiple steps of endocytic trafficking
por: Joseph, Braveen B., et al.
Publicado: (2023)

Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)
por: Verma, Surjeet, et al.
Publicado: (2020)

Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence
por: Facente, Shelley N., et al.
Publicado: (2021)

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro
por: Fred, Senem Merve, et al.
Publicado: (2022)

Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking
por: Tien, Chih-Feng, et al.
Publicado: (2022)

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
por: Browne, Caroline A., et al.
Publicado: (2013)

Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway
por: Liu, Gseping, et al.
Publicado: (1997)

Design of novel disturbing peptides against ACE2 SARS-CoV-2 spike-binding region by computational approaches
por: Zareei, Sara, et al.
Publicado: (2022)

Antidepressant Effects of Rosemary Extracts Associate With Anti-inflammatory Effect and Rebalance of Gut Microbiota
por: Guo, Ying, et al.
Publicado: (2018)

Mechanisms of antidepressant resistance
por: El-Hage, Wissam, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_15en4avt96u8cu7nj84mlo2566