Regulatory T cell function in autoimmune disease

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoi...

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Detalles Bibliográficos
Autores principales: Rajendeeran, Anandi, Tenbrock, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
VSI: Autoimmune disorder
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716637/
https://www.ncbi.nlm.nih.gov/pubmed/35005594
http://dx.doi.org/10.1016/j.jtauto.2021.100130
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author Rajendeeran, Anandi
Tenbrock, Klaus
author_facet Rajendeeran, Anandi
Tenbrock, Klaus
author_sort Rajendeeran, Anandi
collection PubMed
description Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.
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spelling pubmed-87166372022-01-06 Regulatory T cell function in autoimmune disease Rajendeeran, Anandi Tenbrock, Klaus J Transl Autoimmun VSI: Autoimmune disorder Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function. Elsevier 2021-10-30 /pmc/articles/PMC8716637/ /pubmed/35005594 http://dx.doi.org/10.1016/j.jtauto.2021.100130 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle VSI: Autoimmune disorder
Rajendeeran, Anandi
Tenbrock, Klaus
Regulatory T cell function in autoimmune disease
title Regulatory T cell function in autoimmune disease
title_full Regulatory T cell function in autoimmune disease
title_fullStr Regulatory T cell function in autoimmune disease
title_full_unstemmed Regulatory T cell function in autoimmune disease
title_short Regulatory T cell function in autoimmune disease
title_sort regulatory t cell function in autoimmune disease
topic VSI: Autoimmune disorder
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716637/
https://www.ncbi.nlm.nih.gov/pubmed/35005594
http://dx.doi.org/10.1016/j.jtauto.2021.100130
work_keys_str_mv AT rajendeerananandi regulatorytcellfunctioninautoimmunedisease
AT tenbrockklaus regulatorytcellfunctioninautoimmunedisease

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