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The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy
Laminectomy is commonly performed to treat degenerative spinal diseases by reducing compression on the spinal cord and nerve roots. The postoperative epidural fibrosis and epidural adhesions may result in failed back surgery syndrome, which is characterized by the symptoms of lower back pain or leg...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716848/ https://www.ncbi.nlm.nih.gov/pubmed/34975478 http://dx.doi.org/10.3389/fphar.2021.774316 |
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author | Ding, Qing Wei, Qi Sheng, Gaohong Wang, Shanxi Jing, Shaoze Ma, Tian Zhang, Ruizhuo Wang, Tianqi Li, Wenkai Tang, Xiangyu Wu, Hua Liu, Chaoxu |
author_facet | Ding, Qing Wei, Qi Sheng, Gaohong Wang, Shanxi Jing, Shaoze Ma, Tian Zhang, Ruizhuo Wang, Tianqi Li, Wenkai Tang, Xiangyu Wu, Hua Liu, Chaoxu |
author_sort | Ding, Qing |
collection | PubMed |
description | Laminectomy is commonly performed to treat degenerative spinal diseases by reducing compression on the spinal cord and nerve roots. The postoperative epidural fibrosis and epidural adhesions may result in failed back surgery syndrome, which is characterized by the symptoms of lower back pain or leg pain. There is currently no satisfactory treatment for this complication. The pathological processes of epidural fibrosis and epidural adhesions are relevant to the proliferation of fibroblasts, transdifferentiation of fibroblasts into myofibroblasts, and the excessive deposition of extracellular matrix (ECM) protein. According to reports, transforming growth factor-β1 (TGF-β1) played a vital role in the development of fibrosis by promoting aforementioned processes. Decorin, an endogenous proteoglycan and natural inhibitor of TGF-β1, has exhibited prominent anti-fibrosis activity in various scar formation and fibrosis models of many organs. However, the preventive effect of decorin on epidural fibrosis and epidural adhesions requires further investigation. Here, we investigated the therapeutic effects and potential mechanisms of decorin on epidural fibrosis and epidural adhesions. Our results indicated that decorin could significantly suppress the TGF-β1-induced proliferation, transdifferentiation, and extracellular matrix production in primary fibroblasts. Furthermore, Smad2/3 signaling pathway had been demonstrated to be involved in the preventive effect of decorin. Moreover, administration of decorin in vivo could notably inhibit epidural fibrosis and epidural adhesions after laminectomy. To date, there is no approved therapy to target TGF-β1 for the treatment of epidural fibrosis and epidural adhesions after laminectomy. Our research proved the anti-fibrosis effect of decorin, which may provide an effective and promising treatment for epidural fibrosis and epidural adhesions. |
format | Online Article Text |
id | pubmed-8716848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87168482021-12-31 The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy Ding, Qing Wei, Qi Sheng, Gaohong Wang, Shanxi Jing, Shaoze Ma, Tian Zhang, Ruizhuo Wang, Tianqi Li, Wenkai Tang, Xiangyu Wu, Hua Liu, Chaoxu Front Pharmacol Pharmacology Laminectomy is commonly performed to treat degenerative spinal diseases by reducing compression on the spinal cord and nerve roots. The postoperative epidural fibrosis and epidural adhesions may result in failed back surgery syndrome, which is characterized by the symptoms of lower back pain or leg pain. There is currently no satisfactory treatment for this complication. The pathological processes of epidural fibrosis and epidural adhesions are relevant to the proliferation of fibroblasts, transdifferentiation of fibroblasts into myofibroblasts, and the excessive deposition of extracellular matrix (ECM) protein. According to reports, transforming growth factor-β1 (TGF-β1) played a vital role in the development of fibrosis by promoting aforementioned processes. Decorin, an endogenous proteoglycan and natural inhibitor of TGF-β1, has exhibited prominent anti-fibrosis activity in various scar formation and fibrosis models of many organs. However, the preventive effect of decorin on epidural fibrosis and epidural adhesions requires further investigation. Here, we investigated the therapeutic effects and potential mechanisms of decorin on epidural fibrosis and epidural adhesions. Our results indicated that decorin could significantly suppress the TGF-β1-induced proliferation, transdifferentiation, and extracellular matrix production in primary fibroblasts. Furthermore, Smad2/3 signaling pathway had been demonstrated to be involved in the preventive effect of decorin. Moreover, administration of decorin in vivo could notably inhibit epidural fibrosis and epidural adhesions after laminectomy. To date, there is no approved therapy to target TGF-β1 for the treatment of epidural fibrosis and epidural adhesions after laminectomy. Our research proved the anti-fibrosis effect of decorin, which may provide an effective and promising treatment for epidural fibrosis and epidural adhesions. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8716848/ /pubmed/34975478 http://dx.doi.org/10.3389/fphar.2021.774316 Text en Copyright © 2021 Ding, Wei, Sheng, Wang, Jing, Ma, Zhang, Wang, Li, Tang, Wu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ding, Qing Wei, Qi Sheng, Gaohong Wang, Shanxi Jing, Shaoze Ma, Tian Zhang, Ruizhuo Wang, Tianqi Li, Wenkai Tang, Xiangyu Wu, Hua Liu, Chaoxu The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy |
title | The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy |
title_full | The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy |
title_fullStr | The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy |
title_full_unstemmed | The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy |
title_short | The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy |
title_sort | preventive effect of decorin on epidural fibrosis and epidural adhesions after laminectomy |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716848/ https://www.ncbi.nlm.nih.gov/pubmed/34975478 http://dx.doi.org/10.3389/fphar.2021.774316 |
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