A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line

Iron oxides have become increasingly popular for their use as a diagnostic and therapeutic tool in oncology. This study aimed to improve pharmacological valuable of Fe(3)O(4), which may be use to diagnosis colorectal cancers (CRC). Here, we have developed chitosan (CS) coated Fe(3)O(4) through a cos...

Descripción completa

Detalles Bibliográficos
Autores principales: Alkahtane, Abdullah A., Alghamdi, Hamzah A., Aljasham, Alanoud T., Alkahtani, Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717146/
https://www.ncbi.nlm.nih.gov/pubmed/35002403
http://dx.doi.org/10.1016/j.sjbs.2021.08.078
_version_ 1784624475647508480
author Alkahtane, Abdullah A.
Alghamdi, Hamzah A.
Aljasham, Alanoud T.
Alkahtani, Saad
author_facet Alkahtane, Abdullah A.
Alghamdi, Hamzah A.
Aljasham, Alanoud T.
Alkahtani, Saad
author_sort Alkahtane, Abdullah A.
collection PubMed
description Iron oxides have become increasingly popular for their use as a diagnostic and therapeutic tool in oncology. This study aimed to improve pharmacological valuable of Fe(3)O(4), which may be use to diagnosis colorectal cancers (CRC). Here, we have developed chitosan (CS) coated Fe(3)O(4) through a cost-effective procedure. First, we determined the characterization of OA-C-Fe(3)O(4) by FTIR, UV–Vis spectra, and TEM. Then, we evaluated the photodynamic therapeutic (PDT) activity of OA-C-Fe(3)O(4) in human colorectal carcinoma cell lines (HCT 116). Current results revealed that the light-induced enhanced reactive oxygen species (ROS) activity of the nanoparticles (NPs) and caused cell death via the activity of caspase 9/3. The in vitro magnetic resonance imaging (MRI) experiments in (HCT 116) and human embryonic kidney cells (HEK 293) illustrated that nanohybrid is an effective MRI contrasting agents for the diagnosis of colorectal cancer.
format Online
Article
Text
id pubmed-8717146
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-87171462022-01-06 A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line Alkahtane, Abdullah A. Alghamdi, Hamzah A. Aljasham, Alanoud T. Alkahtani, Saad Saudi J Biol Sci Original Article Iron oxides have become increasingly popular for their use as a diagnostic and therapeutic tool in oncology. This study aimed to improve pharmacological valuable of Fe(3)O(4), which may be use to diagnosis colorectal cancers (CRC). Here, we have developed chitosan (CS) coated Fe(3)O(4) through a cost-effective procedure. First, we determined the characterization of OA-C-Fe(3)O(4) by FTIR, UV–Vis spectra, and TEM. Then, we evaluated the photodynamic therapeutic (PDT) activity of OA-C-Fe(3)O(4) in human colorectal carcinoma cell lines (HCT 116). Current results revealed that the light-induced enhanced reactive oxygen species (ROS) activity of the nanoparticles (NPs) and caused cell death via the activity of caspase 9/3. The in vitro magnetic resonance imaging (MRI) experiments in (HCT 116) and human embryonic kidney cells (HEK 293) illustrated that nanohybrid is an effective MRI contrasting agents for the diagnosis of colorectal cancer. Elsevier 2022-01 2021-08-28 /pmc/articles/PMC8717146/ /pubmed/35002403 http://dx.doi.org/10.1016/j.sjbs.2021.08.078 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Alkahtane, Abdullah A.
Alghamdi, Hamzah A.
Aljasham, Alanoud T.
Alkahtani, Saad
A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line
title A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line
title_full A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line
title_fullStr A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line
title_full_unstemmed A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line
title_short A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line
title_sort possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (hct-116) cell line
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717146/
https://www.ncbi.nlm.nih.gov/pubmed/35002403
http://dx.doi.org/10.1016/j.sjbs.2021.08.078
work_keys_str_mv AT alkahtaneabdullaha apossibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT alghamdihamzaha apossibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT aljashamalanoudt apossibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT alkahtanisaad apossibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT alkahtaneabdullaha possibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT alghamdihamzaha possibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT aljashamalanoudt possibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline
AT alkahtanisaad possibletheranosticapproachofchitosancoatedironoxidenanoparticlesagainsthumancolorectalcarcinomahct116cellline

Ejemplares similares