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Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules

A functional cure of chronic hepatitis B requires eliminating the hepatitis B virus (HBV)-encoded surface antigen (HBsAg), which can suppress immune responses. STOPS are phosphorothioated single-stranded oligonucleotides containing novel chemistries that significantly reduce HBsAgs produced by HBV-i...

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Detalles Bibliográficos
Autores principales:	Kao, C. Cheng, Nie, Yuchun, Ren, Suping, De Costa, N. Tilani T.S., Pandey, Rajendra K., Hong, Jin, Smith, David B., Symons, Julian A., Beigelman, Leonid, Blatt, Lawrence M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717253/ https://www.ncbi.nlm.nih.gov/pubmed/35024245 http://dx.doi.org/10.1016/j.omtn.2021.12.013

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