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Candidates for Balancing Selection in Leishmania donovani Complex Parasites
The Leishmania donovani species complex is the causative agent of visceral leishmaniasis, which cause 20–40,000 fatalities a year. Here, we conduct a screen for balancing selection in this species complex. We used 384 publicly available L. donovani and L. infantum genomes, and sequence 93 isolates o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717319/ https://www.ncbi.nlm.nih.gov/pubmed/34865011 http://dx.doi.org/10.1093/gbe/evab265 |
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author | Grace, Cooper Alastair Forrester, Sarah Silva, Vladimir Costa Carvalho, Kátia Silene Sousa Kilford, Hannah Chew, Yen Peng James, Sally Costa, Dorcas L Mottram, Jeremy C Costa, Carlos C H N Jeffares, Daniel C |
author_facet | Grace, Cooper Alastair Forrester, Sarah Silva, Vladimir Costa Carvalho, Kátia Silene Sousa Kilford, Hannah Chew, Yen Peng James, Sally Costa, Dorcas L Mottram, Jeremy C Costa, Carlos C H N Jeffares, Daniel C |
author_sort | Grace, Cooper Alastair |
collection | PubMed |
description | The Leishmania donovani species complex is the causative agent of visceral leishmaniasis, which cause 20–40,000 fatalities a year. Here, we conduct a screen for balancing selection in this species complex. We used 384 publicly available L. donovani and L. infantum genomes, and sequence 93 isolates of L. infantum from Brazil to describe the global diversity of this species complex. We identify five genetically distinct populations that are sufficiently represented by genomic data to search for signatures of selection. We find that signals of balancing selection are generally not shared between populations, consistent with transient adaptive events, rather than long-term balancing selection. We then apply multiple diversity metrics to identify candidate genes with robust signatures of balancing selection, identifying a curated set of 24 genes with robust signatures. These include zeta toxin, nodulin-like, and flagellum attachment proteins. This study highlights the extent of genetic divergence between L. donovani complex parasites and provides genes for further study. |
format | Online Article Text |
id | pubmed-8717319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-87173192022-01-05 Candidates for Balancing Selection in Leishmania donovani Complex Parasites Grace, Cooper Alastair Forrester, Sarah Silva, Vladimir Costa Carvalho, Kátia Silene Sousa Kilford, Hannah Chew, Yen Peng James, Sally Costa, Dorcas L Mottram, Jeremy C Costa, Carlos C H N Jeffares, Daniel C Genome Biol Evol Research Article The Leishmania donovani species complex is the causative agent of visceral leishmaniasis, which cause 20–40,000 fatalities a year. Here, we conduct a screen for balancing selection in this species complex. We used 384 publicly available L. donovani and L. infantum genomes, and sequence 93 isolates of L. infantum from Brazil to describe the global diversity of this species complex. We identify five genetically distinct populations that are sufficiently represented by genomic data to search for signatures of selection. We find that signals of balancing selection are generally not shared between populations, consistent with transient adaptive events, rather than long-term balancing selection. We then apply multiple diversity metrics to identify candidate genes with robust signatures of balancing selection, identifying a curated set of 24 genes with robust signatures. These include zeta toxin, nodulin-like, and flagellum attachment proteins. This study highlights the extent of genetic divergence between L. donovani complex parasites and provides genes for further study. Oxford University Press 2021-12-02 /pmc/articles/PMC8717319/ /pubmed/34865011 http://dx.doi.org/10.1093/gbe/evab265 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Grace, Cooper Alastair Forrester, Sarah Silva, Vladimir Costa Carvalho, Kátia Silene Sousa Kilford, Hannah Chew, Yen Peng James, Sally Costa, Dorcas L Mottram, Jeremy C Costa, Carlos C H N Jeffares, Daniel C Candidates for Balancing Selection in Leishmania donovani Complex Parasites |
title | Candidates for Balancing Selection in Leishmania donovani Complex Parasites |
title_full | Candidates for Balancing Selection in Leishmania donovani Complex Parasites |
title_fullStr | Candidates for Balancing Selection in Leishmania donovani Complex Parasites |
title_full_unstemmed | Candidates for Balancing Selection in Leishmania donovani Complex Parasites |
title_short | Candidates for Balancing Selection in Leishmania donovani Complex Parasites |
title_sort | candidates for balancing selection in leishmania donovani complex parasites |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717319/ https://www.ncbi.nlm.nih.gov/pubmed/34865011 http://dx.doi.org/10.1093/gbe/evab265 |
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