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Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis

[Image: see text] Integrins α4β1/ α9β1 are important in the pathogenesis and progression of inflammatory and autoimmune diseases by their roles in leukocyte activation and trafficking. Natalizumab, a monoclonal antibody selectively targeting α4β1 integrin and blocking leukocyte trafficking to the ce...

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Detalles Bibliográficos
Autores principales:	Gilon, Chaim, Klazas, Michal, Lahiani, Adi, Schumacher-Klinger, Adi, Merzbach, Shira, Naoum, Johnny N., Ovadia, Haim, Rubin, Limor, Cornell-Kennon, Susan, Schaefer, Erik M., Katzhendler, Jehoshua, Marcinkiewicz, Cezary, Hoffman, Amnon, Lazarovici, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717366/ https://www.ncbi.nlm.nih.gov/pubmed/34977904 http://dx.doi.org/10.1021/jacsau.1c00496

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