Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Display Altered Proteomes at Early Stages of Differentiation

[Image: see text] Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by loss of motor neurons (MN) in the spinal cord leading to progressive muscle atrophy and weakness. SMA is caused by mutations in the survival motor neuron 1 (SMN1) gene, resulting in...

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Autores principales: Varderidou-Minasian, Suzy, Verheijen, Bert M., Harschnitz, Oliver, Kling, Sandra, Karst, Henk, van der Pol, W. Ludo, Pasterkamp, R. Jeroen, Altelaar, Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717385/
https://www.ncbi.nlm.nih.gov/pubmed/34984269
http://dx.doi.org/10.1021/acsomega.1c04688

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