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Toward Glycomaterials with Selectivity as Well as Affinity
[Image: see text] Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity toward carbohydrate binding proteins (e.g., lectins) due to the nonlinear enhancement from the cluster glycoside effect. This affinity gain has potential in applications from diagnostics...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717392/ https://www.ncbi.nlm.nih.gov/pubmed/34984416 http://dx.doi.org/10.1021/jacsau.1c00352 |
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author | Richards, Sarah-Jane Gibson, Matthew I. |
author_facet | Richards, Sarah-Jane Gibson, Matthew I. |
author_sort | Richards, Sarah-Jane |
collection | PubMed |
description | [Image: see text] Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity toward carbohydrate binding proteins (e.g., lectins) due to the nonlinear enhancement from the cluster glycoside effect. This affinity gain has potential in applications from diagnostics, biosensors, and targeted delivery to anti-infectives and in an understanding of basic glycobiology. This perspective highlights the question of selectivity, which is less often addressed due to the reductionist nature of glycomaterials and the promiscuity of many lectins. The use of macromolecular features, including architecture, heterogeneous ligand display, and the installation of non-natural glycans, to address this challenge is discussed, and examples of selectivity gains are given. |
format | Online Article Text |
id | pubmed-8717392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87173922022-01-03 Toward Glycomaterials with Selectivity as Well as Affinity Richards, Sarah-Jane Gibson, Matthew I. JACS Au [Image: see text] Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity toward carbohydrate binding proteins (e.g., lectins) due to the nonlinear enhancement from the cluster glycoside effect. This affinity gain has potential in applications from diagnostics, biosensors, and targeted delivery to anti-infectives and in an understanding of basic glycobiology. This perspective highlights the question of selectivity, which is less often addressed due to the reductionist nature of glycomaterials and the promiscuity of many lectins. The use of macromolecular features, including architecture, heterogeneous ligand display, and the installation of non-natural glycans, to address this challenge is discussed, and examples of selectivity gains are given. American Chemical Society 2021-10-11 /pmc/articles/PMC8717392/ /pubmed/34984416 http://dx.doi.org/10.1021/jacsau.1c00352 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Richards, Sarah-Jane Gibson, Matthew I. Toward Glycomaterials with Selectivity as Well as Affinity |
title | Toward Glycomaterials with Selectivity as Well as
Affinity |
title_full | Toward Glycomaterials with Selectivity as Well as
Affinity |
title_fullStr | Toward Glycomaterials with Selectivity as Well as
Affinity |
title_full_unstemmed | Toward Glycomaterials with Selectivity as Well as
Affinity |
title_short | Toward Glycomaterials with Selectivity as Well as
Affinity |
title_sort | toward glycomaterials with selectivity as well as
affinity |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717392/ https://www.ncbi.nlm.nih.gov/pubmed/34984416 http://dx.doi.org/10.1021/jacsau.1c00352 |
work_keys_str_mv | AT richardssarahjane towardglycomaterialswithselectivityaswellasaffinity AT gibsonmatthewi towardglycomaterialswithselectivityaswellasaffinity |