ProtSeq: Toward high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes

We demonstrate early progress toward constructing a high-throughput, single-molecule protein sequencing technology utilizing barcoded DNA aptamers (binders) to recognize terminal amino acids of peptides (targets) tethered on a next-generation sequencing chip. DNA binders deposit unique, amino acid-i...

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Detalles Bibliográficos
Autores principales: Hong, Jessica M., Gibbons, Michael, Bashir, Ali, Wu, Diana, Shao, Shirley, Cutts, Zachary, Chavarha, Mariya, Chen, Ye, Schiff, Lauren, Foster, Mikelle, Church, Victoria A., Ching, Llyke, Ahadi, Sara, Hieu-Thao Le, Anna, Tran, Alexander, Dimon, Michelle, Coram, Marc, Williams, Brian, Jess, Phillip, Berndl, Marc, Pawlosky, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717419/
https://www.ncbi.nlm.nih.gov/pubmed/35005536
http://dx.doi.org/10.1016/j.isci.2021.103586

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