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IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT(+) HIVGag-specific T cells

HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 can enhance HIV-specific T cell function is largely unknown. In the present...

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Detalles Bibliográficos
Autores principales:	Cheng, Jie, Myers, Timothy G., Levinger, Callie, Kumar, Princy, Kumar, Jai, Goshu, Bruktawit A., Bosque, Alberto, Catalfamo, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717455/ https://www.ncbi.nlm.nih.gov/pubmed/35005538 http://dx.doi.org/10.1016/j.isci.2021.103588

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