Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model

To develop effective adoptive cell transfer therapy using T cell receptor (TCR)-engineered T cells, it is critical to isolate tumor-reactive TCRs that have potent anti-tumor activity. In humans, tumor-infiltrating lymphocytes (TILs) have been reported to contain CD8(+)PD-1(+) T cells that express tu...

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Detalles Bibliográficos
Autores principales: Terada, Koji, Kondo, Kenta, Ishigaki, Hirohito, Nagashima, Ayaka, Satooka, Hiroki, Nagano, Seiji, Masuda, Kyoko, Kawamura, Teruhisa, Hirata, Takako, Ogasawara, Kazumasa, Itoh, Yasushi, Kawamoto, Hiroshi, Agata, Yasutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717465/
https://www.ncbi.nlm.nih.gov/pubmed/35024435
http://dx.doi.org/10.1016/j.omto.2021.12.003

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