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Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports

BACKGROUND: Coronavirus disease 2019 (COVID-19) patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections. There is a possibility that such infections are missed or misdiagnosed, in which case patients may suffer higher morbidity and mortality. COVI...

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Autores principales: Upadhyay, Shalini, Bharara, Tanisha, Khandait, Manisha, Chawdhry, Ankit, Sharma, Bharat Bhushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717511/
https://www.ncbi.nlm.nih.gov/pubmed/35071564
http://dx.doi.org/10.12998/wjcc.v9.i36.11338
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author Upadhyay, Shalini
Bharara, Tanisha
Khandait, Manisha
Chawdhry, Ankit
Sharma, Bharat Bhushan
author_facet Upadhyay, Shalini
Bharara, Tanisha
Khandait, Manisha
Chawdhry, Ankit
Sharma, Bharat Bhushan
author_sort Upadhyay, Shalini
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections. There is a possibility that such infections are missed or misdiagnosed, in which case patients may suffer higher morbidity and mortality. COVID-19 infection, aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal infections. Mucormycosis is one of the opportunistic fungal infections that may affect treated COVID patients. CASE SUMMARY: We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 recovery. All the patients had diabetes and a history of systemic corticosteroids for treatment of COVID-19. The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5 ± 14.5 (7–30) d. All patients underwent debridement and were started on antifungal therapy. One patient was referred to a higher center for further management, but the others responded well to treatment and showed signs of improvement at the last follow-up. CONCLUSION: Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival.
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spelling pubmed-87175112022-01-20 Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports Upadhyay, Shalini Bharara, Tanisha Khandait, Manisha Chawdhry, Ankit Sharma, Bharat Bhushan World J Clin Cases Case Report BACKGROUND: Coronavirus disease 2019 (COVID-19) patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections. There is a possibility that such infections are missed or misdiagnosed, in which case patients may suffer higher morbidity and mortality. COVID-19 infection, aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal infections. Mucormycosis is one of the opportunistic fungal infections that may affect treated COVID patients. CASE SUMMARY: We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 recovery. All the patients had diabetes and a history of systemic corticosteroids for treatment of COVID-19. The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5 ± 14.5 (7–30) d. All patients underwent debridement and were started on antifungal therapy. One patient was referred to a higher center for further management, but the others responded well to treatment and showed signs of improvement at the last follow-up. CONCLUSION: Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival. Baishideng Publishing Group Inc 2021-12-26 2021-12-26 /pmc/articles/PMC8717511/ /pubmed/35071564 http://dx.doi.org/10.12998/wjcc.v9.i36.11338 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Upadhyay, Shalini
Bharara, Tanisha
Khandait, Manisha
Chawdhry, Ankit
Sharma, Bharat Bhushan
Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
title Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
title_full Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
title_fullStr Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
title_full_unstemmed Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
title_short Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
title_sort mucormycosis – resurgence of a deadly opportunist during covid-19 pandemic: four case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717511/
https://www.ncbi.nlm.nih.gov/pubmed/35071564
http://dx.doi.org/10.12998/wjcc.v9.i36.11338
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