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Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports
BACKGROUND: Coronavirus disease 2019 (COVID-19) patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections. There is a possibility that such infections are missed or misdiagnosed, in which case patients may suffer higher morbidity and mortality. COVI...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717511/ https://www.ncbi.nlm.nih.gov/pubmed/35071564 http://dx.doi.org/10.12998/wjcc.v9.i36.11338 |
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author | Upadhyay, Shalini Bharara, Tanisha Khandait, Manisha Chawdhry, Ankit Sharma, Bharat Bhushan |
author_facet | Upadhyay, Shalini Bharara, Tanisha Khandait, Manisha Chawdhry, Ankit Sharma, Bharat Bhushan |
author_sort | Upadhyay, Shalini |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections. There is a possibility that such infections are missed or misdiagnosed, in which case patients may suffer higher morbidity and mortality. COVID-19 infection, aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal infections. Mucormycosis is one of the opportunistic fungal infections that may affect treated COVID patients. CASE SUMMARY: We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 recovery. All the patients had diabetes and a history of systemic corticosteroids for treatment of COVID-19. The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5 ± 14.5 (7–30) d. All patients underwent debridement and were started on antifungal therapy. One patient was referred to a higher center for further management, but the others responded well to treatment and showed signs of improvement at the last follow-up. CONCLUSION: Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival. |
format | Online Article Text |
id | pubmed-8717511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-87175112022-01-20 Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports Upadhyay, Shalini Bharara, Tanisha Khandait, Manisha Chawdhry, Ankit Sharma, Bharat Bhushan World J Clin Cases Case Report BACKGROUND: Coronavirus disease 2019 (COVID-19) patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections. There is a possibility that such infections are missed or misdiagnosed, in which case patients may suffer higher morbidity and mortality. COVID-19 infection, aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal infections. Mucormycosis is one of the opportunistic fungal infections that may affect treated COVID patients. CASE SUMMARY: We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 recovery. All the patients had diabetes and a history of systemic corticosteroids for treatment of COVID-19. The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5 ± 14.5 (7–30) d. All patients underwent debridement and were started on antifungal therapy. One patient was referred to a higher center for further management, but the others responded well to treatment and showed signs of improvement at the last follow-up. CONCLUSION: Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival. Baishideng Publishing Group Inc 2021-12-26 2021-12-26 /pmc/articles/PMC8717511/ /pubmed/35071564 http://dx.doi.org/10.12998/wjcc.v9.i36.11338 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Upadhyay, Shalini Bharara, Tanisha Khandait, Manisha Chawdhry, Ankit Sharma, Bharat Bhushan Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports |
title | Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports |
title_full | Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports |
title_fullStr | Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports |
title_full_unstemmed | Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports |
title_short | Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports |
title_sort | mucormycosis – resurgence of a deadly opportunist during covid-19 pandemic: four case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717511/ https://www.ncbi.nlm.nih.gov/pubmed/35071564 http://dx.doi.org/10.12998/wjcc.v9.i36.11338 |
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