A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering

[Image: see text] A novel porous calcium silicate (CS)-enhanced small intestinal submucosa (SIS) scaffold was prepared by freeze-drying to mimic the natural extracellular matrix environment for bone tissue engineering. The micro-morphology, physicochemical properties, biological characteristics, and...

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Autores principales: Wang, Mei, Li, Bowen, Liu, Yuhua, Tang, Lin, Zhang, Yi, Xie, Qiufei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717537/
https://www.ncbi.nlm.nih.gov/pubmed/34984303
http://dx.doi.org/10.1021/acsomega.1c05623
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author Wang, Mei
Li, Bowen
Liu, Yuhua
Tang, Lin
Zhang, Yi
Xie, Qiufei
author_facet Wang, Mei
Li, Bowen
Liu, Yuhua
Tang, Lin
Zhang, Yi
Xie, Qiufei
author_sort Wang, Mei
collection PubMed
description [Image: see text] A novel porous calcium silicate (CS)-enhanced small intestinal submucosa (SIS) scaffold was prepared by freeze-drying to mimic the natural extracellular matrix environment for bone tissue engineering. The micro-morphology, physicochemical properties, biological characteristics, and effects on osteogenic differentiation in vitro were explored; the effects on promoting bone formation in vivo were evaluated. The composite scaffold had an ideal three-dimensional porous structure. The amount of calcium silicate played a significant role in improving mechanical properties and promoting osteogenic differentiation. The SIS/2CS scaffold promoted proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells; it also significantly increased osteogenesis in vivo. This novel composite polymer scaffold has potential applications in bone tissue engineering.
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spelling pubmed-87175372022-01-03 A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering Wang, Mei Li, Bowen Liu, Yuhua Tang, Lin Zhang, Yi Xie, Qiufei ACS Omega [Image: see text] A novel porous calcium silicate (CS)-enhanced small intestinal submucosa (SIS) scaffold was prepared by freeze-drying to mimic the natural extracellular matrix environment for bone tissue engineering. The micro-morphology, physicochemical properties, biological characteristics, and effects on osteogenic differentiation in vitro were explored; the effects on promoting bone formation in vivo were evaluated. The composite scaffold had an ideal three-dimensional porous structure. The amount of calcium silicate played a significant role in improving mechanical properties and promoting osteogenic differentiation. The SIS/2CS scaffold promoted proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells; it also significantly increased osteogenesis in vivo. This novel composite polymer scaffold has potential applications in bone tissue engineering. American Chemical Society 2021-12-17 /pmc/articles/PMC8717537/ /pubmed/34984303 http://dx.doi.org/10.1021/acsomega.1c05623 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wang, Mei
Li, Bowen
Liu, Yuhua
Tang, Lin
Zhang, Yi
Xie, Qiufei
A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering
title A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering
title_full A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering
title_fullStr A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering
title_full_unstemmed A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering
title_short A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering
title_sort novel bionic extracellular matrix polymer scaffold enhanced by calcium silicate for bone tissue engineering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717537/
https://www.ncbi.nlm.nih.gov/pubmed/34984303
http://dx.doi.org/10.1021/acsomega.1c05623
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