Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition

α-Synuclein (α-Syn) is the major protein component of Lewy bodies, a key pathological feature of Parkinson’s disease (PD). The manganese ion Mn(2+) has been identified as an environmental risk factor of PD. However, it remains unclear how Mn(2+) regulates α-Syn aggregation. Here, we discovered that...

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Detalles Bibliográficos
Autores principales: Xu, Bingkuan, Huang, Shuai, Liu, Yinghui, Wan, Chun, Gu, Yuanyuan, Wang, Dianliang, Yu, Haijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717548/
https://www.ncbi.nlm.nih.gov/pubmed/34871547
http://dx.doi.org/10.1016/j.jbc.2021.101469

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