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Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-...

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Autores principales: Cao, Xi, Guo, Lei, Cai, Caihong, Kong, Fandong, Yuan, Jingzhe, Gai, Cuijuan, Dai, Haofu, Wang, Pei, Mei, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717711/
https://www.ncbi.nlm.nih.gov/pubmed/34976948
http://dx.doi.org/10.3389/fchem.2021.773703
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author Cao, Xi
Guo, Lei
Cai, Caihong
Kong, Fandong
Yuan, Jingzhe
Gai, Cuijuan
Dai, Haofu
Wang, Pei
Mei, Wenli
author_facet Cao, Xi
Guo, Lei
Cai, Caihong
Kong, Fandong
Yuan, Jingzhe
Gai, Cuijuan
Dai, Haofu
Wang, Pei
Mei, Wenli
author_sort Cao, Xi
collection PubMed
description Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh(2)(OCOCF(3))(4)-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC(50) values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC(50) values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.
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spelling pubmed-87177112021-12-31 Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 Cao, Xi Guo, Lei Cai, Caihong Kong, Fandong Yuan, Jingzhe Gai, Cuijuan Dai, Haofu Wang, Pei Mei, Wenli Front Chem Chemistry Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh(2)(OCOCF(3))(4)-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC(50) values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC(50) values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8717711/ /pubmed/34976948 http://dx.doi.org/10.3389/fchem.2021.773703 Text en Copyright © 2021 Cao, Guo, Cai, Kong, Yuan, Gai, Dai, Wang and Mei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Cao, Xi
Guo, Lei
Cai, Caihong
Kong, Fandong
Yuan, Jingzhe
Gai, Cuijuan
Dai, Haofu
Wang, Pei
Mei, Wenli
Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
title Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
title_full Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
title_fullStr Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
title_full_unstemmed Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
title_short Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
title_sort metabolites from the mangrove-derived fungus cladosporium sp. hnwsw-1
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717711/
https://www.ncbi.nlm.nih.gov/pubmed/34976948
http://dx.doi.org/10.3389/fchem.2021.773703
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