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A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient

Dulaglutide is an injectable glucagon-like peptide-1 receptor agonist approved for the treatment of adults with type 2 diabetes. Angioedema is defined as self-limiting edema, localized in the deeper layers of the skin and mucosa. Angioedema can be hereditary or acquired which can be allergic due to...

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Detalles Bibliográficos
Autores principales: Karakousis, Nikolaos, Kostakopoulos, Nikolaos A, Georgakopoulou, Vasiliki E, Pyrgioti, Elisavet E, Georgakopoulos, Petros N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717822/
https://www.ncbi.nlm.nih.gov/pubmed/34987924
http://dx.doi.org/10.7759/cureus.20041
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author Karakousis, Nikolaos
Kostakopoulos, Nikolaos A
Georgakopoulou, Vasiliki E
Pyrgioti, Elisavet E
Georgakopoulos, Petros N
author_facet Karakousis, Nikolaos
Kostakopoulos, Nikolaos A
Georgakopoulou, Vasiliki E
Pyrgioti, Elisavet E
Georgakopoulos, Petros N
author_sort Karakousis, Nikolaos
collection PubMed
description Dulaglutide is an injectable glucagon-like peptide-1 receptor agonist approved for the treatment of adults with type 2 diabetes. Angioedema is defined as self-limiting edema, localized in the deeper layers of the skin and mucosa. Angioedema can be hereditary or acquired which can be allergic due to reactions to foods, insect bites and stings, and latex, drug-induced, caused by physical stimuli and associated with lupus erythematosus and hypereosinophilia. Angioedema represents a rare adverse event of glucagon-like peptide-1 receptor agonists. The only glucagon-like peptide-1 receptor agonist that has been mentioned to induce angioedema in literature is exenatide. We report the first case of dulaglutide-associated angioedema in a 72-year-old male in order to point out to the clinicians this potential rare side effect of this drug and its clinical significance.
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spelling pubmed-87178222022-01-04 A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient Karakousis, Nikolaos Kostakopoulos, Nikolaos A Georgakopoulou, Vasiliki E Pyrgioti, Elisavet E Georgakopoulos, Petros N Cureus Internal Medicine Dulaglutide is an injectable glucagon-like peptide-1 receptor agonist approved for the treatment of adults with type 2 diabetes. Angioedema is defined as self-limiting edema, localized in the deeper layers of the skin and mucosa. Angioedema can be hereditary or acquired which can be allergic due to reactions to foods, insect bites and stings, and latex, drug-induced, caused by physical stimuli and associated with lupus erythematosus and hypereosinophilia. Angioedema represents a rare adverse event of glucagon-like peptide-1 receptor agonists. The only glucagon-like peptide-1 receptor agonist that has been mentioned to induce angioedema in literature is exenatide. We report the first case of dulaglutide-associated angioedema in a 72-year-old male in order to point out to the clinicians this potential rare side effect of this drug and its clinical significance. Cureus 2021-11-30 /pmc/articles/PMC8717822/ /pubmed/34987924 http://dx.doi.org/10.7759/cureus.20041 Text en Copyright © 2021, Karakousis et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Karakousis, Nikolaos
Kostakopoulos, Nikolaos A
Georgakopoulou, Vasiliki E
Pyrgioti, Elisavet E
Georgakopoulos, Petros N
A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient
title A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient
title_full A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient
title_fullStr A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient
title_full_unstemmed A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient
title_short A Rare Case of Dulaglutide-Associated Angioedema in a Male Patient
title_sort rare case of dulaglutide-associated angioedema in a male patient
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717822/
https://www.ncbi.nlm.nih.gov/pubmed/34987924
http://dx.doi.org/10.7759/cureus.20041
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