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Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG

BACKGROUND: Platelet-derived growth factor receptor (PDGFR) signaling has been directly implicated in pediatric high-grade gliomagenesis. This study evaluated the safety and tolerability of crenolanib, a potent, selective inhibitor of PDGFR-mediated phosphorylation, in pediatric patients with high-g...

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Detalles Bibliográficos
Autores principales:	Tinkle, Christopher L, Broniscer, Alberto, Chiang, Jason, Campagne, Olivia, Huang, Jie, Orr, Brent A, Li, Xiaoyu, Patay, Zoltan, Zhang, Jinghui, Baker, Suzanne J, Merchant, Thomas E, Jain, Vinay, Onar-Thomas, Arzu, Stewart, Clinton F, Wetmore, Cynthia, Gajjar, Amar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717895/ https://www.ncbi.nlm.nih.gov/pubmed/34993482 http://dx.doi.org/10.1093/noajnl/vdab179

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