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Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants
Phosphatidylinositol (PtdIns) is one type of phospholipid comprising an inositol head group and two fatty acid chains covalently linked to the diacylglycerol group. In addition to their roles as compositions of cell membranes, phosphorylated PtdIns derivatives, termed phosphoinositides, execute a wi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717918/ https://www.ncbi.nlm.nih.gov/pubmed/34975993 http://dx.doi.org/10.3389/fpls.2021.803635 |
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author | Mao, Yanbo Tan, Shutang |
author_facet | Mao, Yanbo Tan, Shutang |
author_sort | Mao, Yanbo |
collection | PubMed |
description | Phosphatidylinositol (PtdIns) is one type of phospholipid comprising an inositol head group and two fatty acid chains covalently linked to the diacylglycerol group. In addition to their roles as compositions of cell membranes, phosphorylated PtdIns derivatives, termed phosphoinositides, execute a wide range of regulatory functions. PtdIns can be phosphorylated by various lipid kinases at 3-, 4- and/or 5- hydroxyls of the inositol ring, and the phosphorylated forms, including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P(2), PtdIns(4,5)P(2), can be reversibly dephosphorylated by distinct lipid phosphatases. Amongst many other types, the SUPPRESSOR OF ACTIN (SAC) family of phosphoinositide phosphatases recently emerged as important regulators in multiple growth and developmental processes in plants. Here, we review recent advances on the biological functions, cellular activities, and molecular mechanisms of SAC domain-containing phosphoinositide phosphatases in plants. With a focus on those studies in the model plant Arabidopsis thaliana together with progresses in other plants, we highlight the important roles of subcellular localizations and substrate preferences of various SAC isoforms in their functions. |
format | Online Article Text |
id | pubmed-8717918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87179182021-12-31 Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants Mao, Yanbo Tan, Shutang Front Plant Sci Plant Science Phosphatidylinositol (PtdIns) is one type of phospholipid comprising an inositol head group and two fatty acid chains covalently linked to the diacylglycerol group. In addition to their roles as compositions of cell membranes, phosphorylated PtdIns derivatives, termed phosphoinositides, execute a wide range of regulatory functions. PtdIns can be phosphorylated by various lipid kinases at 3-, 4- and/or 5- hydroxyls of the inositol ring, and the phosphorylated forms, including PtdIns3P, PtdIns4P, PtdIns5P, PtdIns(3,5)P(2), PtdIns(4,5)P(2), can be reversibly dephosphorylated by distinct lipid phosphatases. Amongst many other types, the SUPPRESSOR OF ACTIN (SAC) family of phosphoinositide phosphatases recently emerged as important regulators in multiple growth and developmental processes in plants. Here, we review recent advances on the biological functions, cellular activities, and molecular mechanisms of SAC domain-containing phosphoinositide phosphatases in plants. With a focus on those studies in the model plant Arabidopsis thaliana together with progresses in other plants, we highlight the important roles of subcellular localizations and substrate preferences of various SAC isoforms in their functions. Frontiers Media S.A. 2021-12-16 /pmc/articles/PMC8717918/ /pubmed/34975993 http://dx.doi.org/10.3389/fpls.2021.803635 Text en Copyright © 2021 Mao and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Mao, Yanbo Tan, Shutang Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants |
title | Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants |
title_full | Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants |
title_fullStr | Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants |
title_full_unstemmed | Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants |
title_short | Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants |
title_sort | functions and mechanisms of sac phosphoinositide phosphatases in plants |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717918/ https://www.ncbi.nlm.nih.gov/pubmed/34975993 http://dx.doi.org/10.3389/fpls.2021.803635 |
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