Measurement Biases Distort Cell-Free DNA Fragmentation Profiles and Define the Sensitivity of Metagenomic Cell-Free DNA Sequencing Assays

BACKGROUND: Metagenomic sequencing of microbial cell-free DNA (cfDNA) in blood and urine is increasingly used as a tool for unbiased infection screening. The sensitivity of metagenomic cfDNA sequencing assays is determined by the efficiency by which the assay recovers microbial cfDNA vs host-specifi...

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Detalles Bibliográficos
Autores principales: Chang, Adrienne, Mzava, Omary, Lenz, Joan S, Cheng, Alexandre P, Burnham, Philip, Motley, S Timothy, Bennett, Crissa, Connelly, John T, Dadhania, Darshana M, Suthanthiran, Manikkam, Lee, John R, Steadman, Amy, De Vlaminck, Iwijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718127/
https://www.ncbi.nlm.nih.gov/pubmed/34718476
http://dx.doi.org/10.1093/clinchem/hvab142

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