Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease

Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role in PAD remains elusive. Here, we show that the dietary tryptophan-derived uremic solutes including indox...

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Detalles Bibliográficos
Autores principales: Arinze, Nkiruka V., Yin, Wenqing, Lotfollahzadeh, Saran, Napoleon, Marc Arthur, Richards, Sean, Walker, Joshua A., Belghasem, Mostafa, Ravid, Jonathan D., Hassan Kamel, Mohamed, Whelan, Stephen A., Lee, Norman, Siracuse, Jeffrey J., Anderson, Stephan, Farber, Alik, Sherr, David, Francis, Jean, Hamburg, Naomi M., Rahimi, Nader, Chitalia, Vipul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718145/
https://www.ncbi.nlm.nih.gov/pubmed/34752422
http://dx.doi.org/10.1172/JCI142260

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