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Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction

Acute myocardial infarction (AMI) induces blood leukocytosis, which correlates inversely with patient survival. The molecular mechanisms leading to leukocytosis in the infarcted heart remain poorly understood. Using an AMI mouse model, we identified gasdermin D (GSDMD) in activated leukocytes early...

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Detalles Bibliográficos
Autores principales:	Jiang, Kai, Tu, Zizhuo, Chen, Kun, Xu, Yue, Chen, Feng, Xu, Sheng, Shi, Tingting, Qian, Jie, Shen, Lan, Hwa, John, Wang, Dandan, Xiang, Yaozu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718151/ https://www.ncbi.nlm.nih.gov/pubmed/34752417 http://dx.doi.org/10.1172/JCI151268

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