15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation

Altered redox biology challenges all cells, with compensatory responses often determining a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine-binding protein 1 (PEBP1), hydroperoxy-phos...

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Detalles Bibliográficos
Autores principales: Nagasaki, Tadao, Schuyler, Alexander J., Zhao, Jinming, Samovich, Svetlana N., Yamada, Kazuhiro, Deng, Yanhan, Ginebaugh, Scott P., Christenson, Stephanie A., Woodruff, Prescott G., Fahy, John V., Trudeau, John B., Stoyanovsky, Detcho, Ray, Anuradha, Tyurina, Yulia Y., Kagan, Valerian E., Wenzel, Sally E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718153/
https://www.ncbi.nlm.nih.gov/pubmed/34762602
http://dx.doi.org/10.1172/JCI151685

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