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Ischemic Stroke in the Young

The purpose of this article is to address several challenging questions in the management of young patients (those age 60 and under) who present with ischemic stroke. Do genetic thrombophilic states, strongly associated with venous thrombosis, independently cause arterial events in adults? Should ca...

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Detalles Bibliográficos
Autores principales: Berkman, Samuel A., Song, Shlee S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718160/
https://www.ncbi.nlm.nih.gov/pubmed/33870763
http://dx.doi.org/10.1177/10760296211002274
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author Berkman, Samuel A.
Song, Shlee S.
author_facet Berkman, Samuel A.
Song, Shlee S.
author_sort Berkman, Samuel A.
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description The purpose of this article is to address several challenging questions in the management of young patients (those age 60 and under) who present with ischemic stroke. Do genetic thrombophilic states, strongly associated with venous thrombosis, independently cause arterial events in adults? Should cases of patent foramen ovale be closed with mechanical devices in patients with cryptogenic stroke? What are the optimal treatments for cerebral vein thrombosis, carotid artery dissection, and antiphospholipid syndrome and are DOACs acceptable treatment for these indications? What is the mechanism underlying large vessel stroke in patients with COVID-19? This is a narrative review. We searched PubMed and Embase and American College of physicians Journal club database for English language articles since 2000 looking mainly at randomized clinical trials, Meta analyses, Cochran reviews as well as some research articles viewed to be cutting edge regarding anticoagulation and cerebrovascular disease. Searches were done entering cerebral vein thrombosis, carotid dissection, anticoagulation therapy and stroke, antiphospholipid antibody and stroke, stroke in young adults, cryptogenic stroke and anticoagulation, patent foramen ovale and cryptogenic stroke, COVID-19 and stroke.
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spelling pubmed-87181602021-12-31 Ischemic Stroke in the Young Berkman, Samuel A. Song, Shlee S. Clin Appl Thromb Hemost Original Manuscript The purpose of this article is to address several challenging questions in the management of young patients (those age 60 and under) who present with ischemic stroke. Do genetic thrombophilic states, strongly associated with venous thrombosis, independently cause arterial events in adults? Should cases of patent foramen ovale be closed with mechanical devices in patients with cryptogenic stroke? What are the optimal treatments for cerebral vein thrombosis, carotid artery dissection, and antiphospholipid syndrome and are DOACs acceptable treatment for these indications? What is the mechanism underlying large vessel stroke in patients with COVID-19? This is a narrative review. We searched PubMed and Embase and American College of physicians Journal club database for English language articles since 2000 looking mainly at randomized clinical trials, Meta analyses, Cochran reviews as well as some research articles viewed to be cutting edge regarding anticoagulation and cerebrovascular disease. Searches were done entering cerebral vein thrombosis, carotid dissection, anticoagulation therapy and stroke, antiphospholipid antibody and stroke, stroke in young adults, cryptogenic stroke and anticoagulation, patent foramen ovale and cryptogenic stroke, COVID-19 and stroke. SAGE Publications 2021-04-19 /pmc/articles/PMC8718160/ /pubmed/33870763 http://dx.doi.org/10.1177/10760296211002274 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
Berkman, Samuel A.
Song, Shlee S.
Ischemic Stroke in the Young
title Ischemic Stroke in the Young
title_full Ischemic Stroke in the Young
title_fullStr Ischemic Stroke in the Young
title_full_unstemmed Ischemic Stroke in the Young
title_short Ischemic Stroke in the Young
title_sort ischemic stroke in the young
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718160/
https://www.ncbi.nlm.nih.gov/pubmed/33870763
http://dx.doi.org/10.1177/10760296211002274
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