Cargando…

SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)

BACKGROUND: Cemented hip arthroplasty requires applying a layer of polymethylmethacrylate (cement) in the space between the bone and the prosthetic stem. This can be achieved using 2 techniques: the thick-layer technique (requires a layer of at least 2 mm to surround an undersized prosthetic stem),...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodríguez, Daniel, Carnaval, Thiago, del Carmen, Marcos, Palomar-Muñoz, Azahara, Cortés-Romera, Montserrat, Agulló, José-Luis, Videla, Sebastián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718198/
https://www.ncbi.nlm.nih.gov/pubmed/34967362
http://dx.doi.org/10.1097/MD.0000000000028299
_version_ 1784624672185253888
author Rodríguez, Daniel
Carnaval, Thiago
del Carmen, Marcos
Palomar-Muñoz, Azahara
Cortés-Romera, Montserrat
Agulló, José-Luis
Videla, Sebastián
author_facet Rodríguez, Daniel
Carnaval, Thiago
del Carmen, Marcos
Palomar-Muñoz, Azahara
Cortés-Romera, Montserrat
Agulló, José-Luis
Videla, Sebastián
author_sort Rodríguez, Daniel
collection PubMed
description BACKGROUND: Cemented hip arthroplasty requires applying a layer of polymethylmethacrylate (cement) in the space between the bone and the prosthetic stem. This can be achieved using 2 techniques: the thick-layer technique (requires a layer of at least 2 mm to surround an undersized prosthetic stem), and the thin-layer technique (requires a thin layer of cement, so that the prosthetic stem fills the femoral medullary canal). Both approaches have excellent long-term clinical and radiological outcomes, although an implant's insertion into the bone generates inevitable bone mass and bone metabolic changes around it. Combination of single photon emission computed tomography and computed tomography scan (SPECT-CT) imaging combines the single photon emission computed tomography's ability to provide detailed bone metabolism assessment with the computed tomography scan's capacity to provide a meticulous anatomical study. METHODS: This is a single center, open label, randomized clinical trial, performed in the premises of the Bellvitge University Hospital. Participants will be randomly assigned to the Thick-layer technique group (Exeter V40 Cemented Femoral Stem) or to the French paradox technique group (Müller Straight Stem). All participants will have a SPECT-CT scan study at 3, 6, 12, and 24 months after the surgery. DISCUSSION: Surgical distress itself and the implant's insertion into the bone may cause microvascular changes that alter periprosthetic bone mass and bone metabolism. To the best of our knowledge, there are no studies using SPECT-CT to compare bone metabolism evolution in the postoperative period between these 2 surgical cementation techniques. We aim to provide information in this regard that could help decision making in complicated implant cases and, maybe, pave the way for larger, and methodologically improved studies. TRIAL REGISTRATION: NCT05010733 (August 18, 2021).
format Online
Article
Text
id pubmed-8718198
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-87181982022-01-03 SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA) Rodríguez, Daniel Carnaval, Thiago del Carmen, Marcos Palomar-Muñoz, Azahara Cortés-Romera, Montserrat Agulló, José-Luis Videla, Sebastián Medicine (Baltimore) 7100 BACKGROUND: Cemented hip arthroplasty requires applying a layer of polymethylmethacrylate (cement) in the space between the bone and the prosthetic stem. This can be achieved using 2 techniques: the thick-layer technique (requires a layer of at least 2 mm to surround an undersized prosthetic stem), and the thin-layer technique (requires a thin layer of cement, so that the prosthetic stem fills the femoral medullary canal). Both approaches have excellent long-term clinical and radiological outcomes, although an implant's insertion into the bone generates inevitable bone mass and bone metabolic changes around it. Combination of single photon emission computed tomography and computed tomography scan (SPECT-CT) imaging combines the single photon emission computed tomography's ability to provide detailed bone metabolism assessment with the computed tomography scan's capacity to provide a meticulous anatomical study. METHODS: This is a single center, open label, randomized clinical trial, performed in the premises of the Bellvitge University Hospital. Participants will be randomly assigned to the Thick-layer technique group (Exeter V40 Cemented Femoral Stem) or to the French paradox technique group (Müller Straight Stem). All participants will have a SPECT-CT scan study at 3, 6, 12, and 24 months after the surgery. DISCUSSION: Surgical distress itself and the implant's insertion into the bone may cause microvascular changes that alter periprosthetic bone mass and bone metabolism. To the best of our knowledge, there are no studies using SPECT-CT to compare bone metabolism evolution in the postoperative period between these 2 surgical cementation techniques. We aim to provide information in this regard that could help decision making in complicated implant cases and, maybe, pave the way for larger, and methodologically improved studies. TRIAL REGISTRATION: NCT05010733 (August 18, 2021). Lippincott Williams & Wilkins 2021-12-30 /pmc/articles/PMC8718198/ /pubmed/34967362 http://dx.doi.org/10.1097/MD.0000000000028299 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 7100
Rodríguez, Daniel
Carnaval, Thiago
del Carmen, Marcos
Palomar-Muñoz, Azahara
Cortés-Romera, Montserrat
Agulló, José-Luis
Videla, Sebastián
SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)
title SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)
title_full SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)
title_fullStr SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)
title_full_unstemmed SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)
title_short SPECT-CT metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: A protocol for a randomized controlled clinical trial (SPECT-PROTMA)
title_sort spect-ct metabolic and morphological study of 2 types of cemented hip stem prostheses in primary total hip arthroplasty patients: a protocol for a randomized controlled clinical trial (spect-protma)
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718198/
https://www.ncbi.nlm.nih.gov/pubmed/34967362
http://dx.doi.org/10.1097/MD.0000000000028299
work_keys_str_mv AT rodriguezdaniel spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma
AT carnavalthiago spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma
AT delcarmenmarcos spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma
AT palomarmunozazahara spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma
AT cortesromeramontserrat spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma
AT agullojoseluis spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma
AT videlasebastian spectctmetabolicandmorphologicalstudyof2typesofcementedhipstemprosthesesinprimarytotalhiparthroplastypatientsaprotocolforarandomizedcontrolledclinicaltrialspectprotma