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Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic spread to most of the world's countries during its first and subsequent waves, often increasing in an almost exponential trend. Traditional Chinese medicine has played a vital role in this epidemic. Nonetheless, size of effect, certai...

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Autores principales: Wang, Xin, Wang, Yafeng, Lu, Hairu, Yan, Luqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718199/
https://www.ncbi.nlm.nih.gov/pubmed/34967369
http://dx.doi.org/10.1097/MD.0000000000028375
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author Wang, Xin
Wang, Yafeng
Lu, Hairu
Yan, Luqing
author_facet Wang, Xin
Wang, Yafeng
Lu, Hairu
Yan, Luqing
author_sort Wang, Xin
collection PubMed
description BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic spread to most of the world's countries during its first and subsequent waves, often increasing in an almost exponential trend. Traditional Chinese medicine has played a vital role in this epidemic. Nonetheless, size of effect, certainty of the evidence, optimal therapy regimen, and selection of patients who are likely to benefit most are factors that remain to be evaluated. This study aims to assess and rank where appropriate the relative effects of interventions for the prevention and treatment of COVID-19. METHOD: This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. We will search Chinese electronic database (CBM, Wanfang and CNKI) and international electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) for identify all relevant published studies. Study selection, data collection and assessment of study bias will be conducted independently by a pair of independent reviewers. The Cochrane risk of bias tool will be used for the risk of bias assessment. We will use the advance of GRADE to rate the certainty of network meta-analysis. Data analysis will be performed with R-3.6.1 and WinBUGS software. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: This systematic review and network meta-analysis will use both direct and indirect evidence to compare the differences of all Traditional Chinese medicine treatment for COVID-19 patients, providing decision-makers and clinical practitioners with a complete, high-quality and up-to-date synthesis of evidence.
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spelling pubmed-87181992022-01-03 Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis Wang, Xin Wang, Yafeng Lu, Hairu Yan, Luqing Medicine (Baltimore) 4900 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic spread to most of the world's countries during its first and subsequent waves, often increasing in an almost exponential trend. Traditional Chinese medicine has played a vital role in this epidemic. Nonetheless, size of effect, certainty of the evidence, optimal therapy regimen, and selection of patients who are likely to benefit most are factors that remain to be evaluated. This study aims to assess and rank where appropriate the relative effects of interventions for the prevention and treatment of COVID-19. METHOD: This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. We will search Chinese electronic database (CBM, Wanfang and CNKI) and international electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) for identify all relevant published studies. Study selection, data collection and assessment of study bias will be conducted independently by a pair of independent reviewers. The Cochrane risk of bias tool will be used for the risk of bias assessment. We will use the advance of GRADE to rate the certainty of network meta-analysis. Data analysis will be performed with R-3.6.1 and WinBUGS software. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: This systematic review and network meta-analysis will use both direct and indirect evidence to compare the differences of all Traditional Chinese medicine treatment for COVID-19 patients, providing decision-makers and clinical practitioners with a complete, high-quality and up-to-date synthesis of evidence. Lippincott Williams & Wilkins 2021-12-30 /pmc/articles/PMC8718199/ /pubmed/34967369 http://dx.doi.org/10.1097/MD.0000000000028375 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle 4900
Wang, Xin
Wang, Yafeng
Lu, Hairu
Yan, Luqing
Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis
title Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis
title_full Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis
title_fullStr Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis
title_full_unstemmed Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis
title_short Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis
title_sort traditional chinese medicine for the prevention and treatment of covid-19: a protocol for systematic review and network meta-analysis
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718199/
https://www.ncbi.nlm.nih.gov/pubmed/34967369
http://dx.doi.org/10.1097/MD.0000000000028375
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