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Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiquitin ligase, can cause juvenile-onset Parkinsonism, probably through impairment of mitophagy. Inhibition of the de-ubiquitinating enzyme USP30 may counter this effect to enhance mitophagy. Using differ...

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Detalles Bibliográficos
Autores principales:	Tsefou, Eliona, Walker, Alison S., Clark, Emily H., Hicks, Amy R., Luft, Christin, Takeda, Kunitoshi, Watanabe, Toru, Ramazio, Bianca, Staddon, James M., Briston, Thomas, Ketteler, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718267/ https://www.ncbi.nlm.nih.gov/pubmed/34704599 http://dx.doi.org/10.1042/BCJ20210508

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