Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer

Secreted phosphoprotein 1 (SPP1) participated in various biological processes in many cancers, including immune response, tumor progression, and prognosis. However, SPP1 in head and neck squamous cell carcinoma (HNSCC) remains unknown. Clinical-genetic data of HNSCC were obtained from The Cancer Gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Bie, Tongwu, Zhang, Xuewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718292/
https://www.ncbi.nlm.nih.gov/pubmed/34977258
http://dx.doi.org/10.1155/2021/8569575
_version_ 1784624691329105920
author Bie, Tongwu
Zhang, Xuewen
author_facet Bie, Tongwu
Zhang, Xuewen
author_sort Bie, Tongwu
collection PubMed
description Secreted phosphoprotein 1 (SPP1) participated in various biological processes in many cancers, including immune response, tumor progression, and prognosis. However, SPP1 in head and neck squamous cell carcinoma (HNSCC) remains unknown. Clinical-genetic data of HNSCC were obtained from The Cancer Genome Atlas (TCGA) database. The differential expression of SPP1 in HNSCC tissues and adjacent normal tissues was quantified by bioinformatics methods and verified by western blot and other differential biological methods. We concluded that SPP1 is significantly upregulated in tumor tissues and can become a prognostic biomarker for HNSCC.
format Online
Article
Text
id pubmed-8718292
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-87182922021-12-31 Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer Bie, Tongwu Zhang, Xuewen J Immunol Res Research Article Secreted phosphoprotein 1 (SPP1) participated in various biological processes in many cancers, including immune response, tumor progression, and prognosis. However, SPP1 in head and neck squamous cell carcinoma (HNSCC) remains unknown. Clinical-genetic data of HNSCC were obtained from The Cancer Genome Atlas (TCGA) database. The differential expression of SPP1 in HNSCC tissues and adjacent normal tissues was quantified by bioinformatics methods and verified by western blot and other differential biological methods. We concluded that SPP1 is significantly upregulated in tumor tissues and can become a prognostic biomarker for HNSCC. Hindawi 2021-12-23 /pmc/articles/PMC8718292/ /pubmed/34977258 http://dx.doi.org/10.1155/2021/8569575 Text en Copyright © 2021 Tongwu Bie and Xuewen Zhang. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bie, Tongwu
Zhang, Xuewen
Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer
title Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer
title_full Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer
title_fullStr Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer
title_full_unstemmed Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer
title_short Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck Cancer
title_sort higher expression of spp1 predicts poorer survival outcomes in head and neck cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718292/
https://www.ncbi.nlm.nih.gov/pubmed/34977258
http://dx.doi.org/10.1155/2021/8569575
work_keys_str_mv AT bietongwu higherexpressionofspp1predictspoorersurvivaloutcomesinheadandneckcancer
AT zhangxuewen higherexpressionofspp1predictspoorersurvivaloutcomesinheadandneckcancer

Ejemplares similares