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Risk factors for death in Welsh infants with a congenital anomaly
OBJECTIVES: To investigate risk factors associated with death of infants with a congenital anomaly in Wales, UK. DESIGN: A population-based cohort study. SETTING: Data from the Welsh Congenital Anomaly Register and Information Service (CARIS) linked to live births and deaths from the Office for Nati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718467/ http://dx.doi.org/10.1136/bmjpo-2021-001205 |
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author | Ho, Peter S Y Quigley, Maria Tucker, David F Kurinczuk, Jenny |
author_facet | Ho, Peter S Y Quigley, Maria Tucker, David F Kurinczuk, Jenny |
author_sort | Ho, Peter S Y |
collection | PubMed |
description | OBJECTIVES: To investigate risk factors associated with death of infants with a congenital anomaly in Wales, UK. DESIGN: A population-based cohort study. SETTING: Data from the Welsh Congenital Anomaly Register and Information Service (CARIS) linked to live births and deaths from the Office for National Statistics. PATIENTS: All live births between 1998 and 2016 with a diagnosis of a congenital anomaly, which was defined as a structural, metabolic, endocrine or genetic defect, as well as rare disease of hereditary origin. MAIN OUTCOME MEASURES: Adjusted ORs (aORs) were estimated for socio-demographic, maternal, infant and intervention factors associated with death in infancy, using logistic regression for all, isolated, multiple and cardiovascular anomalies. RESULTS: 30 424 live births affected by congenital anomalies were identified, including 1044 infants who died by the age of 1 year (infant mortality rate: 16.5 per 10 000 live births, case fatality: 3.4%, 30.3% of all infant deaths). Risk factors for infant death were non-white versus white ethnicity (aOR: 2.25; 95% CI: 1.77–2.86); parous versus nulliparous (aOR: 1.24; 95% CI: 1.08–1.41); smoking during pregnancy versus non-smokers/ex-smokers (aOR: 1.20; 95% CI: 1.02–1.40); preterm versus term birth (aOR: 4.38; 95% CI 3.86–4.98); female versus male infants (aOR: 1.28; 95% CI: 1.13–1.46) and the earlier years of the birth cohort (aOR: 0.96; 95% CI: 0.95–0.98 per yearly increase). Infants with a cardiovascular anomaly who received surgery had a lower odds of death than those who did not (aOR: 0.34; 95% CI: 0.15–0.75). Preterm birth was a significant factor for death for all anomalies but the effect of the other characteristics varied according to anomaly group. CONCLUSIONS: Nearly a third of all infant deaths had an associated anomaly. Improving access to prenatal care, smoking cessation advice, optimising care for preterm infants and surgery may help lower the risk of infant death. |
format | Online Article Text |
id | pubmed-8718467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-87184672022-01-12 Risk factors for death in Welsh infants with a congenital anomaly Ho, Peter S Y Quigley, Maria Tucker, David F Kurinczuk, Jenny BMJ Paediatr Open Congenital Abnormality OBJECTIVES: To investigate risk factors associated with death of infants with a congenital anomaly in Wales, UK. DESIGN: A population-based cohort study. SETTING: Data from the Welsh Congenital Anomaly Register and Information Service (CARIS) linked to live births and deaths from the Office for National Statistics. PATIENTS: All live births between 1998 and 2016 with a diagnosis of a congenital anomaly, which was defined as a structural, metabolic, endocrine or genetic defect, as well as rare disease of hereditary origin. MAIN OUTCOME MEASURES: Adjusted ORs (aORs) were estimated for socio-demographic, maternal, infant and intervention factors associated with death in infancy, using logistic regression for all, isolated, multiple and cardiovascular anomalies. RESULTS: 30 424 live births affected by congenital anomalies were identified, including 1044 infants who died by the age of 1 year (infant mortality rate: 16.5 per 10 000 live births, case fatality: 3.4%, 30.3% of all infant deaths). Risk factors for infant death were non-white versus white ethnicity (aOR: 2.25; 95% CI: 1.77–2.86); parous versus nulliparous (aOR: 1.24; 95% CI: 1.08–1.41); smoking during pregnancy versus non-smokers/ex-smokers (aOR: 1.20; 95% CI: 1.02–1.40); preterm versus term birth (aOR: 4.38; 95% CI 3.86–4.98); female versus male infants (aOR: 1.28; 95% CI: 1.13–1.46) and the earlier years of the birth cohort (aOR: 0.96; 95% CI: 0.95–0.98 per yearly increase). Infants with a cardiovascular anomaly who received surgery had a lower odds of death than those who did not (aOR: 0.34; 95% CI: 0.15–0.75). Preterm birth was a significant factor for death for all anomalies but the effect of the other characteristics varied according to anomaly group. CONCLUSIONS: Nearly a third of all infant deaths had an associated anomaly. Improving access to prenatal care, smoking cessation advice, optimising care for preterm infants and surgery may help lower the risk of infant death. BMJ Publishing Group 2021-12-28 /pmc/articles/PMC8718467/ http://dx.doi.org/10.1136/bmjpo-2021-001205 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Congenital Abnormality Ho, Peter S Y Quigley, Maria Tucker, David F Kurinczuk, Jenny Risk factors for death in Welsh infants with a congenital anomaly |
title | Risk factors for death in Welsh infants with a congenital anomaly |
title_full | Risk factors for death in Welsh infants with a congenital anomaly |
title_fullStr | Risk factors for death in Welsh infants with a congenital anomaly |
title_full_unstemmed | Risk factors for death in Welsh infants with a congenital anomaly |
title_short | Risk factors for death in Welsh infants with a congenital anomaly |
title_sort | risk factors for death in welsh infants with a congenital anomaly |
topic | Congenital Abnormality |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718467/ http://dx.doi.org/10.1136/bmjpo-2021-001205 |
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