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Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models

Alzheimer’s disease effects a large percentage of elderly dementia patients and is diagnosed on the basis of amyloid plaques and neurofibrillary tangles (NFTs) present in the brain. Urinary incontinence (UI) is often found in the elderly populations and multiple studies have shown that it is more co...

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Autores principales: Bartolone, Sarah N., Sharma, Prasun, Chancellor, Michael B., Lamb, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718555/
https://www.ncbi.nlm.nih.gov/pubmed/34975457
http://dx.doi.org/10.3389/fnagi.2021.777819
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author Bartolone, Sarah N.
Sharma, Prasun
Chancellor, Michael B.
Lamb, Laura E.
author_facet Bartolone, Sarah N.
Sharma, Prasun
Chancellor, Michael B.
Lamb, Laura E.
author_sort Bartolone, Sarah N.
collection PubMed
description Alzheimer’s disease effects a large percentage of elderly dementia patients and is diagnosed on the basis of amyloid plaques and neurofibrillary tangles (NFTs) present in the brain. Urinary incontinence (UI) is often found in the elderly populations and multiple studies have shown that it is more common in Alzheimer’s disease patients than those with normal cognitive function. However, the link between increased UI and Alzheimer’s disease is still unclear. Amyloid plaques and NFTs present in micturition centers of the brain could cause a loss of signal to the bladder, resulting in the inability to properly void. Additionally, as Alzheimer’s disease progresses, patients become less likely to recognize the need or understand the appropriate time and place to void. There are several treatments for UI targeting the muscarinic and β3 adrenergic receptors, which are present in the bladder and the brain. While these treatments may aid in UI, they often have effects on the brain with cognitive impairment side-effects. Acetylcholine esterase inhibitors are often used in treatment of Alzheimer’s disease and directly oppose effects of anti-muscarinics used for UI, making UI management in Alzheimer’s disease patients difficult. There are currently over 200 pre-clinical models of Alzheimer’s disease, however, little research has been done on voiding disfunction in these models. There is preliminary data suggesting these models have similar voiding behavior to Alzheimer’s disease patients but much more research is needed to understand the link between UI and Alzheimer’s disease and discover better treatment options for managing both simultaneously.
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spelling pubmed-87185552022-01-01 Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models Bartolone, Sarah N. Sharma, Prasun Chancellor, Michael B. Lamb, Laura E. Front Aging Neurosci Aging Neuroscience Alzheimer’s disease effects a large percentage of elderly dementia patients and is diagnosed on the basis of amyloid plaques and neurofibrillary tangles (NFTs) present in the brain. Urinary incontinence (UI) is often found in the elderly populations and multiple studies have shown that it is more common in Alzheimer’s disease patients than those with normal cognitive function. However, the link between increased UI and Alzheimer’s disease is still unclear. Amyloid plaques and NFTs present in micturition centers of the brain could cause a loss of signal to the bladder, resulting in the inability to properly void. Additionally, as Alzheimer’s disease progresses, patients become less likely to recognize the need or understand the appropriate time and place to void. There are several treatments for UI targeting the muscarinic and β3 adrenergic receptors, which are present in the bladder and the brain. While these treatments may aid in UI, they often have effects on the brain with cognitive impairment side-effects. Acetylcholine esterase inhibitors are often used in treatment of Alzheimer’s disease and directly oppose effects of anti-muscarinics used for UI, making UI management in Alzheimer’s disease patients difficult. There are currently over 200 pre-clinical models of Alzheimer’s disease, however, little research has been done on voiding disfunction in these models. There is preliminary data suggesting these models have similar voiding behavior to Alzheimer’s disease patients but much more research is needed to understand the link between UI and Alzheimer’s disease and discover better treatment options for managing both simultaneously. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC8718555/ /pubmed/34975457 http://dx.doi.org/10.3389/fnagi.2021.777819 Text en Copyright © 2021 Bartolone, Sharma, Chancellor and Lamb. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Bartolone, Sarah N.
Sharma, Prasun
Chancellor, Michael B.
Lamb, Laura E.
Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models
title Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models
title_full Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models
title_fullStr Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models
title_full_unstemmed Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models
title_short Urinary Incontinence and Alzheimer’s Disease: Insights From Patients and Preclinical Models
title_sort urinary incontinence and alzheimer’s disease: insights from patients and preclinical models
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718555/
https://www.ncbi.nlm.nih.gov/pubmed/34975457
http://dx.doi.org/10.3389/fnagi.2021.777819
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