Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations

Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. Previous studies have suggested that Dynorphin A (DynA) mediates some patho...

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Detalles Bibliográficos
Autores principales: Perini, D. Aurora, Aguilella-Arzo, Marcel, Alcaraz, Antonio, Perálvarez-Marín, Alex, Queralt-Martín, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718563/
https://www.ncbi.nlm.nih.gov/pubmed/35024095
http://dx.doi.org/10.1016/j.csbj.2021.12.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718563/
https://www.ncbi.nlm.nih.gov/pubmed/35024095
http://dx.doi.org/10.1016/j.csbj.2021.12.021

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