Therapeutic effiacy of T cells expressing chimeric antigen receptor derived from a mesothelin-specific scFv in orthotopic human pancreatic cancer animal models

Novel CAR T cells targeting mesothelin (MSLN) expressed on pancreatic cancer cells were developed to overcome the limit of the clinical efficacy of CAR T cell therapy for pancreatic cancer patients. Optimal single-chain variable fragments (scFv) binding to MSLN were selected based on the binding act...

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Detalles Bibliográficos
Autores principales: Lee, Hyeon Ho, Kim, Irene, Kim, Un Kyo, Choi, Suk San, Kim, Tae Yang, Lee, Dahea, Lee, Youngeun, Lee, Jaehee, Jo, Jinhui, Lee, Young-Tae, Lee, Ho Jeong, Kim, Sun Jin, Ahn, Jong Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718570/
https://www.ncbi.nlm.nih.gov/pubmed/34954452
http://dx.doi.org/10.1016/j.neo.2021.12.005

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