Cargando…

Regeneration in Echinoderms: Molecular Advancements

Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates tho...

Descripción completa

Detalles Bibliográficos
Autores principales: Medina-Feliciano, Joshua G., García-Arrarás, José E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718600/
https://www.ncbi.nlm.nih.gov/pubmed/34977019
http://dx.doi.org/10.3389/fcell.2021.768641
_version_ 1784624763782561792
author Medina-Feliciano, Joshua G.
García-Arrarás, José E.
author_facet Medina-Feliciano, Joshua G.
García-Arrarás, José E.
author_sort Medina-Feliciano, Joshua G.
collection PubMed
description Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates thought to be involved in tissue and organ regeneration have been identified. Several of these studies have been done in echinoderms, an animal group that forms part of the deuterostomes along with vertebrates. Echinoderms, with their outstanding regenerative abilities, can provide important insights into the molecular basis of regeneration. Here we review the available data to determine the genes and signaling pathways that have been proposed to be involved in regenerative processes. Our analyses provide a curated list of genes and gene signaling pathways and match them with the different cellular processes of the regenerative response. In this way, the molecular basis of echinoderm regenerative potential is revealed, and is available for comparisons with other animal taxa.
format Online
Article
Text
id pubmed-8718600
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87186002022-01-01 Regeneration in Echinoderms: Molecular Advancements Medina-Feliciano, Joshua G. García-Arrarás, José E. Front Cell Dev Biol Cell and Developmental Biology Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates thought to be involved in tissue and organ regeneration have been identified. Several of these studies have been done in echinoderms, an animal group that forms part of the deuterostomes along with vertebrates. Echinoderms, with their outstanding regenerative abilities, can provide important insights into the molecular basis of regeneration. Here we review the available data to determine the genes and signaling pathways that have been proposed to be involved in regenerative processes. Our analyses provide a curated list of genes and gene signaling pathways and match them with the different cellular processes of the regenerative response. In this way, the molecular basis of echinoderm regenerative potential is revealed, and is available for comparisons with other animal taxa. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC8718600/ /pubmed/34977019 http://dx.doi.org/10.3389/fcell.2021.768641 Text en Copyright © 2021 Medina-Feliciano and García-Arrarás. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Medina-Feliciano, Joshua G.
García-Arrarás, José E.
Regeneration in Echinoderms: Molecular Advancements
title Regeneration in Echinoderms: Molecular Advancements
title_full Regeneration in Echinoderms: Molecular Advancements
title_fullStr Regeneration in Echinoderms: Molecular Advancements
title_full_unstemmed Regeneration in Echinoderms: Molecular Advancements
title_short Regeneration in Echinoderms: Molecular Advancements
title_sort regeneration in echinoderms: molecular advancements
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718600/
https://www.ncbi.nlm.nih.gov/pubmed/34977019
http://dx.doi.org/10.3389/fcell.2021.768641
work_keys_str_mv AT medinafelicianojoshuag regenerationinechinodermsmolecularadvancements
AT garciaarrarasjosee regenerationinechinodermsmolecularadvancements