Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability

Successful cancer therapy is contingent on identifying cancer-specific aberrant phenotypes and their associated vulnerabilities. We recently reported that a subset of almost every cancer type contains a genome-wide defect in RNA Polymerase II-mediated transcription elongation (TE(def)), which impair...

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Detalles Bibliográficos
Autores principales: Muhammad, B., Parks, L.G., Komurov, K., Privette Vinnedge, L.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718660/
https://www.ncbi.nlm.nih.gov/pubmed/34954455
http://dx.doi.org/10.1016/j.tranon.2021.101323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718660/
https://www.ncbi.nlm.nih.gov/pubmed/34954455
http://dx.doi.org/10.1016/j.tranon.2021.101323

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