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Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability
Successful cancer therapy is contingent on identifying cancer-specific aberrant phenotypes and their associated vulnerabilities. We recently reported that a subset of almost every cancer type contains a genome-wide defect in RNA Polymerase II-mediated transcription elongation (TE(def)), which impair...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Neoplasia Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718660/ https://www.ncbi.nlm.nih.gov/pubmed/34954455 http://dx.doi.org/10.1016/j.tranon.2021.101323 |