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Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

The development of nonalcoholic fatty liver disease (NAFLD) is associated with increased reactive oxygen species (ROS) production. Previous observations on the contradictory roles of general control nonderepressible 2 (GCN2) in regulating the hepatic redox state under different nutritional condition...

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Detalles Bibliográficos
Autores principales: Yuan, Juntao, Yu, Zhuoran, Gao, Junling, Luo, Kai, Shen, Xiyue, Cui, Bingqing, Lu, Zhongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718669/
https://www.ncbi.nlm.nih.gov/pubmed/34954499
http://dx.doi.org/10.1016/j.redox.2021.102224