Cargando…

Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China

Background: Previous studies suggested that exposure to air pollution could increase risk of asthma attacks in children. The aim of this study is to investigate the short-term effects of exposure to ambient air pollution on asthma hospital admissions in children in Beijing, a city with serious air p...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Yakun, Kong, Dehui, Fu, Jia, Zhang, Yongqiao, Chen, Yuxiong, Liu, Yanbo, Chang, Zhen'ge, Liu, Yijie, Liu, Xiaole, Xu, Kaifeng, Jiang, Chengyu, Fan, Zhongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718688/
https://www.ncbi.nlm.nih.gov/pubmed/34976938
http://dx.doi.org/10.3389/fpubh.2021.798746
_version_ 1784624782558363648
author Zhao, Yakun
Kong, Dehui
Fu, Jia
Zhang, Yongqiao
Chen, Yuxiong
Liu, Yanbo
Chang, Zhen'ge
Liu, Yijie
Liu, Xiaole
Xu, Kaifeng
Jiang, Chengyu
Fan, Zhongjie
author_facet Zhao, Yakun
Kong, Dehui
Fu, Jia
Zhang, Yongqiao
Chen, Yuxiong
Liu, Yanbo
Chang, Zhen'ge
Liu, Yijie
Liu, Xiaole
Xu, Kaifeng
Jiang, Chengyu
Fan, Zhongjie
author_sort Zhao, Yakun
collection PubMed
description Background: Previous studies suggested that exposure to air pollution could increase risk of asthma attacks in children. The aim of this study is to investigate the short-term effects of exposure to ambient air pollution on asthma hospital admissions in children in Beijing, a city with serious air pollution and high-quality medical care at the same time. Methods: We collected hospital admission data of asthma patients aged ≤ 18 years old from 56 hospitals from 2013 to 2016 in Beijing, China. Time-stratified case-crossover design and conditional Poisson regression were applied to explore the association between risk of asthma admission in children and the daily concentration of six air pollutants [particulate matter ≤ 2.5 μm (PM(2.5)), particulate matter ≤ 10 μm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), carbon monoxide (CO), and ozone (O(3))], adjusting for meteorological factors and other pollutants. Additionally, stratified analyses were performed by age, gender, and season. Results: In the single-pollutant models, higher levels of PM(2.5), SO(2), and NO(2) were significantly associated with increased risk of hospital admission for asthma in children. The strongest effect was observed in NO(2) at lag06 (RR = 1.25, 95%CI: 1.06-1.48), followed by SO(2) at lag05 (RR = 1.17, 95%CI: 1.05–1.31). The robustness of effects of SO(2) and NO(2) were shown in two-pollutant models. Stratified analyses further indicated that pre-school children (aged ≤ 6 years) were more susceptible to SO(2). The effects of SO(2) were stronger in the cold season, while the effects of NO(2) were stronger in the warm season. No significant sex-specific differences were observed. Conclusions: These results suggested that high levels of air pollution had an adverse effect on childhood asthma, even in a region with high-quality healthcare. Therefore, it will be significant to decrease hospital admissions for asthma in children by controlling air pollution emission and avoiding exposure to air pollution.
format Online
Article
Text
id pubmed-8718688
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87186882022-01-01 Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China Zhao, Yakun Kong, Dehui Fu, Jia Zhang, Yongqiao Chen, Yuxiong Liu, Yanbo Chang, Zhen'ge Liu, Yijie Liu, Xiaole Xu, Kaifeng Jiang, Chengyu Fan, Zhongjie Front Public Health Public Health Background: Previous studies suggested that exposure to air pollution could increase risk of asthma attacks in children. The aim of this study is to investigate the short-term effects of exposure to ambient air pollution on asthma hospital admissions in children in Beijing, a city with serious air pollution and high-quality medical care at the same time. Methods: We collected hospital admission data of asthma patients aged ≤ 18 years old from 56 hospitals from 2013 to 2016 in Beijing, China. Time-stratified case-crossover design and conditional Poisson regression were applied to explore the association between risk of asthma admission in children and the daily concentration of six air pollutants [particulate matter ≤ 2.5 μm (PM(2.5)), particulate matter ≤ 10 μm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), carbon monoxide (CO), and ozone (O(3))], adjusting for meteorological factors and other pollutants. Additionally, stratified analyses were performed by age, gender, and season. Results: In the single-pollutant models, higher levels of PM(2.5), SO(2), and NO(2) were significantly associated with increased risk of hospital admission for asthma in children. The strongest effect was observed in NO(2) at lag06 (RR = 1.25, 95%CI: 1.06-1.48), followed by SO(2) at lag05 (RR = 1.17, 95%CI: 1.05–1.31). The robustness of effects of SO(2) and NO(2) were shown in two-pollutant models. Stratified analyses further indicated that pre-school children (aged ≤ 6 years) were more susceptible to SO(2). The effects of SO(2) were stronger in the cold season, while the effects of NO(2) were stronger in the warm season. No significant sex-specific differences were observed. Conclusions: These results suggested that high levels of air pollution had an adverse effect on childhood asthma, even in a region with high-quality healthcare. Therefore, it will be significant to decrease hospital admissions for asthma in children by controlling air pollution emission and avoiding exposure to air pollution. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC8718688/ /pubmed/34976938 http://dx.doi.org/10.3389/fpubh.2021.798746 Text en Copyright © 2021 Zhao, Kong, Fu, Zhang, Chen, Liu, Chang, Liu, Liu, Xu, Jiang and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Zhao, Yakun
Kong, Dehui
Fu, Jia
Zhang, Yongqiao
Chen, Yuxiong
Liu, Yanbo
Chang, Zhen'ge
Liu, Yijie
Liu, Xiaole
Xu, Kaifeng
Jiang, Chengyu
Fan, Zhongjie
Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
title Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
title_full Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
title_fullStr Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
title_full_unstemmed Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
title_short Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
title_sort increased risk of hospital admission for asthma in children from short-term exposure to air pollution: case-crossover evidence from northern china
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718688/
https://www.ncbi.nlm.nih.gov/pubmed/34976938
http://dx.doi.org/10.3389/fpubh.2021.798746
work_keys_str_mv AT zhaoyakun increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT kongdehui increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT fujia increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT zhangyongqiao increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT chenyuxiong increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT liuyanbo increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT changzhenge increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT liuyijie increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT liuxiaole increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT xukaifeng increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT jiangchengyu increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina
AT fanzhongjie increasedriskofhospitaladmissionforasthmainchildrenfromshorttermexposuretoairpollutioncasecrossoverevidencefromnorthernchina