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Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child

Children have been described to show neurological symptoms in acute coronavirus disease 2019 (COVID-19) and multisystemic inflammatory syndrome in children (MIS-C). We present a 2-year-old boy's clinical course of unilateral acute sixth nerve palsy in the context of severe acute respiratory syn...

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Autores principales: Knoflach, Katrin, Holzapfel, Eva, Roser, Timo, Rudolph, Lieselotte, Paolini, Marco, Muenchhoff, Maximilian, Osterman, Andreas, Griese, Matthias, Kappler, Matthias, von Both, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718702/
https://www.ncbi.nlm.nih.gov/pubmed/34976891
http://dx.doi.org/10.3389/fped.2021.756014
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author Knoflach, Katrin
Holzapfel, Eva
Roser, Timo
Rudolph, Lieselotte
Paolini, Marco
Muenchhoff, Maximilian
Osterman, Andreas
Griese, Matthias
Kappler, Matthias
von Both, Ulrich
author_facet Knoflach, Katrin
Holzapfel, Eva
Roser, Timo
Rudolph, Lieselotte
Paolini, Marco
Muenchhoff, Maximilian
Osterman, Andreas
Griese, Matthias
Kappler, Matthias
von Both, Ulrich
author_sort Knoflach, Katrin
collection PubMed
description Children have been described to show neurological symptoms in acute coronavirus disease 2019 (COVID-19) and multisystemic inflammatory syndrome in children (MIS-C). We present a 2-year-old boy's clinical course of unilateral acute sixth nerve palsy in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Onset of the palsy in the otherwise healthy boy occurred seven days after symptoms attributed to acute infection had subsided respectively 3 weeks after onset of respiratory symptoms. SARS-CoV-2 specific IgG was detected in serum as well as in cerebrospinal fluid. The patient showed a prolonged but self-limiting course with a full recovery after three and a half months. This case illustrates in a detailed chronological sequence that sixth cranial nerve involvement may occur as post-infectious, self-limiting complication of pediatric SARS-CoV-2-infection thus expanding the neurological spectrum of symptoms for children with COVID-19. Clinicians should be aware of the possibility of post-infectious sixth nerve palsy related to SARS-CoV-2-infection particularly in view of recent respiratory tract infection or confirmed cases of SARS-CoV-2-infection amongst the patient's close contacts.
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spelling pubmed-87187022022-01-01 Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child Knoflach, Katrin Holzapfel, Eva Roser, Timo Rudolph, Lieselotte Paolini, Marco Muenchhoff, Maximilian Osterman, Andreas Griese, Matthias Kappler, Matthias von Both, Ulrich Front Pediatr Pediatrics Children have been described to show neurological symptoms in acute coronavirus disease 2019 (COVID-19) and multisystemic inflammatory syndrome in children (MIS-C). We present a 2-year-old boy's clinical course of unilateral acute sixth nerve palsy in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Onset of the palsy in the otherwise healthy boy occurred seven days after symptoms attributed to acute infection had subsided respectively 3 weeks after onset of respiratory symptoms. SARS-CoV-2 specific IgG was detected in serum as well as in cerebrospinal fluid. The patient showed a prolonged but self-limiting course with a full recovery after three and a half months. This case illustrates in a detailed chronological sequence that sixth cranial nerve involvement may occur as post-infectious, self-limiting complication of pediatric SARS-CoV-2-infection thus expanding the neurological spectrum of symptoms for children with COVID-19. Clinicians should be aware of the possibility of post-infectious sixth nerve palsy related to SARS-CoV-2-infection particularly in view of recent respiratory tract infection or confirmed cases of SARS-CoV-2-infection amongst the patient's close contacts. Frontiers Media S.A. 2021-12-17 /pmc/articles/PMC8718702/ /pubmed/34976891 http://dx.doi.org/10.3389/fped.2021.756014 Text en Copyright © 2021 Knoflach, Holzapfel, Roser, Rudolph, Paolini, Muenchhoff, Osterman, Griese, Kappler and von Both. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Knoflach, Katrin
Holzapfel, Eva
Roser, Timo
Rudolph, Lieselotte
Paolini, Marco
Muenchhoff, Maximilian
Osterman, Andreas
Griese, Matthias
Kappler, Matthias
von Both, Ulrich
Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
title Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
title_full Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
title_fullStr Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
title_full_unstemmed Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
title_short Case Report: Unilateral Sixth Cranial Nerve Palsy Associated With COVID-19 in a 2-year-old Child
title_sort case report: unilateral sixth cranial nerve palsy associated with covid-19 in a 2-year-old child
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718702/
https://www.ncbi.nlm.nih.gov/pubmed/34976891
http://dx.doi.org/10.3389/fped.2021.756014
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