Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling

BACKGROUND: Radiation therapy (RT) has a suboptimal effect in patients with pancreatic ductal adenocarcinoma (PDAC) due to intrinsic and acquired radioresistance (RR). Comprehensive bioinformatics and microarray analysis revealed that cholesterol biosynthesis (CBS) is involved in the RR of PDAC. We...

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Detalles Bibliográficos
Autores principales: Seshacharyulu, Parthasarathy, Halder, Sushanta, Nimmakayala, Ramakrishna, Rachagani, Satyanarayana, Chaudhary, Sanjib, Atri, Pranita, Chirravuri-Venkata, Ramakanth, Ouellette, Michel M., Carmicheal, Joseph, Gautam, Shailendra K., Vengoji, Raghupathy, Wang, Shuo, Li, Sicong, Smith, Lynette, Talmon, Geoffrey A., Klute, Kelsey, Ly, Quan, Reames, Bradley N, Grem, Jean L, Berim, Lyudmyla, Padussis, James C, Kaur, Sukhwinder, Kumar, Sushil, Ponnusamy, Moorthy P., Jain, Maneesh, Lin, Chi, Batra, Surinder K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718746/
https://www.ncbi.nlm.nih.gov/pubmed/34971971
http://dx.doi.org/10.1016/j.ebiom.2021.103772

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