Cargando…

Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant I79N

Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disease and often results in cardiac remodeling and an increased incidence of sudden cardiac arrest (SCA) and death, especially in youth and young adults. Among thousands of different variants found in HCM patients, varian...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shafaattalab, Sanam, Li, Alison Y, Gunawan, Marvin G, Kim, BaRun, Jayousi, Farah, Maaref, Yasaman, Song, Zhen, Weiss, James N, Solaro, R. John, Qu, Zhilin, Tibbits, Glen F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718794/ https://www.ncbi.nlm.nih.gov/pubmed/34977031 http://dx.doi.org/10.3389/fcell.2021.787581

Ejemplares similares

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C(+/−) During Development
por: Shafaattalab, Sanam, et al.
Publicado: (2023)

Drug screening platform using human induced pluripotent stem cell‐derived atrial cardiomyocytes and optical mapping
por: Gunawan, Marvin G., et al.
Publicado: (2020)

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation
por: Hamledari, Homa, et al.
Publicado: (2022)

Cardiac Troponin T (TNNT2) Mutations in Chinese Dilated Cardiomyopathy Patients
por: Li, Xiaoping, et al.
Publicado: (2014)

Cardiac Troponin T (TNNT2) plays a potential oncogenic role in colorectal carcinogenesis
por: Liu, Yifan, et al.
Publicado: (2023)

Tale of two hearts: a TNNT2 hypertrophic cardiomyopathy case report
por: Pham, Justin H., et al.
Publicado: (2023)

RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes
por: Huang, Haojun, et al.
Publicado: (2022)

Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*
por: Li, Alison Y., et al.
Publicado: (2013)

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations
por: Pioner, Josè Manuel, et al.
Publicado: (2022)

Binding of calcium and magnesium to human cardiac troponin C
por: Rayani, Kaveh, et al.
Publicado: (2021)

Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy
por: Géraud, Justine, et al.
Publicado: (2021)

A novel nonsense mutation in TNNT2 in a Chinese pedigree with hypertrophic cardiomyopathy: A case report
por: Gao, Guangyuan, et al.
Publicado: (2020)

Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients
por: Pua, Chee Jian, et al.
Publicado: (2020)

Structure and Sequence of the Human Fast Skeletal Troponin T (TNNT3) Gene: Insight Into the Evolution of the Gene and the Origin of the Developmentally Regulated Isoforms
por: Stefancsik, Raymund, et al.
Publicado: (2003)

Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants
por: Parbhudayal, Rahana Y., et al.
Publicado: (2020)

MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy
por: Chiti, Enrica, et al.
Publicado: (2021)

Hypertrophic, Dilated, and Arrhythmogenic Cardiomyopathy: Where Are We?
por: El Hadi, Hamza, et al.
Publicado: (2023)

Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes
por: Christidi, Effimia, et al.
Publicado: (2020)

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes
por: Shafaattalab, Sanam, et al.
Publicado: (2019)

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue
por: Laksman, Zachary, et al.
Publicado: (2017)

Biallelic Pathogenic Variants in TNNT3 Associated With Congenital Myopathy
por: Calame, Daniel G., et al.
Publicado: (2021)

Novel autosomal dominant TNNT1 mutation causing nemaline myopathy
por: Konersman, Chamindra G., et al.
Publicado: (2017)

TNNT2 as a potential biomarker for the progression and prognosis of colorectal cancer
por: Jing, Li, et al.
Publicado: (2020)

Prevalence and Phenotypic Expression of Mutations in the MYH7, MYBPC3 and TNNT2 Genes in Families with Hypertrophic Cardiomyopathy in the South of Brazil: A Cross-Sectional Study
por: Mattos, Beatriz Piva e, et al.
Publicado: (2016)

Nemaline myopathy caused byTNNT1 mutations in a Dutch pedigree
por: van der Pol, W Ludo, et al.
Publicado: (2014)

HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3
por: Dilg, Daniel, et al.
Publicado: (2016)

A Novel Homozygous Intronic Variant in TNNT2 Associates With Feline Cardiomyopathy
por: McNamara, James W., et al.
Publicado: (2020)

Adult teleost heart expresses two distinct troponin C paralogs: cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner
por: Genge, Christine E., et al.
Publicado: (2013)

Mechanisms of Arrhythmogenicity in Hypertrophic Cardiomyopathy: Insight From Non-invasive Electrocardiographic Imaging
por: Perez-Alday, Erick A., et al.
Publicado: (2020)

Variant R94C in TNNT2‐Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction
por: Ezekian, Jordan E., et al.
Publicado: (2020)

Cardiac Troponin I and T as Prognostic Markers in Cats with Hypertrophic Cardiomyopathy
por: Langhorn, R., et al.
Publicado: (2014)

Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy
por: Hori, Yasutomo, et al.
Publicado: (2018)

Implications of the complex biology and micro-environment of cardiac sarcomeres in the use of high affinity troponin antibodies as serum biomarkers for cardiac disorders
por: Solaro, Christopher R., et al.
Publicado: (2020)

Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex
por: Manuylov, Nikolay L., et al.
Publicado: (2009)

TNNT1, negatively regulated by miR‐873, promotes the progression of colorectal cancer
por: Chen, Yu, et al.
Publicado: (2019)

WiTNNess: An international natural history study of infantile‐onset TNNT1 myopathy
por: Strauss, Kevin A., et al.
Publicado: (2023)

Risk stratification in cardiomyopathies (dilated, hypertrophic, and arrhythmogenic cardiomyopathy) by cardiac magnetic resonance imaging
por: Guglielmo, Marco, et al.
Publicado: (2021)

Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC
por: Genge, Christine E., et al.
Publicado: (2016)

An In Silico Analysis of Troponin I Mutations in Hypertrophic Cardiomyopathy of Indian Origin
por: Ramachandran, Gayatri, et al.
Publicado: (2013)

Reversed Septal Curvature Is Associated with Elevated Troponin Level in Hypertrophic Cardiomyopathy
por: Rajtar-Salwa, Renata, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bmlj8povijdp86m0jd2j8tdudi